CAS: 128-08-5
分子式: C4H4BrNO2
分子量: 177.98

中文名称: N-溴代丁二酰亚胺
N-溴代琥珀酰亚胺
溴丁二酰亚胺

英文名称: 1-bromo-5-pyrrolidinedione
n-bromosuccinimide
Succinbromimide
NBS

性质描述: 白色至乳白色细粒结晶，微有溴气味。密度2.098g/cm3，熔点180-183℃（分解），在173.5℃时稍分解。溶于四氯化碳。活性溴的*小含量44.5%。

　　N-溴代丁二酰亚胺是一个很有用的溴化剂,它具有高度的选择性,只进攻弱的C—H键即进攻与双键或苯环相连的α-H

　　在强碱（例如DBU）存在下NBS可以将一级酰胺经由霍夫曼重排反应转变为中间产物异氰酸酯。异氰酸酯则与带有羟基的化合物（例如甲醇）反应生成易水解和分离的氨基甲酸。

对烯烃的加成反应
NBS可以和烯烃在水溶液中反应，生成羟基溴代烷。该反应优化的条件是在0℃下，将烯烃溶于二甲基亚砜、二甲基乙缩醛、四氢呋喃、叔丁醇中任意的50%水溶液，在分部加入NBS。该反应的副产物包括α-溴代酮和二溴代化合物。使用新重结晶纯化过的NBS可以减少这些副产物的生成。 如果不加入水，而加入其它亲核试剂，亦可合成其它的双官能团化合物。

　　霍夫曼重排反应中的溴化
　　NBS在强碱（例如1,8-二氮杂 N-溴代丁二酰亚胺双环[5.4.0]十一碳-7-烯（DBU））的状态下可以将一级酰胺经由霍夫曼重排反应产生中间产物异氰酸酯。异氰酸酯则与带有羟基的化合物（例如甲醇）反应生成氨基甲酸，参见 氨基甲酸酯。

质量标准:
外观 白色或微黄色结晶
含量 ≥99%
熔点 173~175℃
有效溴 ≥44%
氯化物 ≤0.05%　
干燥失重 ≤0.5%

用途: 1.溴代反应中溴代试剂。由于其可以缓慢，均匀的释放溴，所以多用于需要控制反应进度的溴代反应中，是比较好的溴代反应试剂。

 

品名	CAS号	规格	包装
N,N-二叔丁基碳二亚胺	691-24-7	99%	25kg/桶
N-苄基马来酰亚胺	1631-26-1	98.5%	25kg/桶
S-苄基琥珀酸	3972-36-9	99%	25kg/桶
二甲基氨基丙基乙基碳酰胺	22572-40-3	99%	25kg/桶
N,N-二环己基碳酰亚胺	538-75-0	99%	25kg/桶
N-(2,4,6-三氯苯)马来酰亚胺	13167-25-4	99%	25kg/桶
1,8-萘内酰亚胺	130-00-7	99%	25kg/桶
DSC	74124-79-1	99%	25kg/桶
FMOC-OSU	82911-69-1	99%	25kg/桶
CPOC-OSU	128595-07-3	99%	25kg/桶
2-BrZ-OSU	128611-93-8	99%	25kg/桶
Z-OSU	13139-17-8	99%	25kg/桶
2-ClZ-OSU	65853-65-8	99%	25kg/桶
3,3-环戊烷戊二酰亚胺	1130-32-1	99%	25kg/桶
N-苯基马来酰亚胺	941-69-5	99.5%	25kg/桶
双马来酰亚胺	13676-54-5	98%	25kg/桶
1,8-萘酰亚胺	81-83-4	99%	25kg/桶
丁二酰亚胺	123-56-8	99%	25kg/桶
N-羟基丁二酰亚胺	6066-82-6	99%	25kg/桶
N-碘代丁二酰亚胺	516-12-1	98%	1kg/包
N-氯代丁二酰亚胺	128-09-6	99%	25kg/桶
N-溴代丁二酰亚胺	128-08-5	98.5%	25kg/桶

N-溴代丁二酰亚胺英文版安全技术说明书
【Product Name】Succinbromimide N-溴代丁二酰亚胺
【Synonyms】
1-Bromo-2,5-pyrrolidinedione
1-Bromopyrrolidine-2,5-dione
【CAS】128-08-5
【Formula】C4H4BrNO2
【Molecular Weight】177.99
【EINECS】204-877-2
【RTECS】WN2275000
【Merck】13,1423
【Beilstein/Gmelin】113916
【Beilstein Reference】5-21-09-00543
【EC Class】harmful, irritant
Physical ａnd Chemical Properties
【Appearance】White to pale yellow solid with a faint promine odor.
【Solubility in water】15 g/L
【Melting Point】174 - 179
【Boiling Point】339
【Vapor Pressure】11
【Density】2.098 g/cm3
【Partition Coefficient】0.04
【Usage】Substance is used in bromination of olefins.
【Vapor Density】6.1
First Aid Measures
【Ingestion】If victim is conscious ａnd alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Immediately flush skin with plenty of soap ａnd water for at least 15 minutes while removing contaminated clothing ａnd shoes. Get medical aid if irritation develops or persists.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper ａnd lower eyelids. Get medical aid immediately.
Handling ａnd Storage
【Storage】Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Keep away from water.
【Handling】Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, ａnd clothing. Avoid ingestion ａnd inhalation.
Hazards Identification
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting ａnd diarrhea.
【Inhalation】May cause irritation of the respiratory tract with burning pain in the nose ａnd throat, coughing, wheezing, shortness of breath ａnd pulmonary edema. May cause effects similar to those described for ingestion.
【Skin】Causes skin irritation.
【Eyes】Causes eye irritation.
【EC Risk Phrase】R 22 34
【EC Safety Phrase】S 26 36/37/39 45
【UN (DOT)】3261
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA＇s eye ａnd face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Poison Class】2
Fire Fighting Measures
【Flash Point】180
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), ａnd full protective gear. During a fire, irritating ａnd highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material ａnd place into a suitable disposal container. Wash area with soap ａnd water. Avoid generating dusty conditions. Provide ventilation.
Stability ａnd Reactivity
【Disposal Code】24
【Stability】Stable under normal temperatures ａnd pressures.
【Incompatibilities】Strong oxidizing agents; strong acids; strong bases; iron ａnd iron salts; aniline; diallylsulfide; hydrazine hydrate; propionitrile; dibenzoyl peroxide + 4-toluic acid.
【Decomposition】Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide.
Transport Information
【UN Number】3261
【HS Code】2925 19 95