表皮生长因子E4127-0.1MG

分类抗体

级别优级纯GR

产品规格SIGMA E4127-0.1MG

CAS62229-50-9

用途范围生物科研

保存温度2-8℃

英文名称Epidermal Growth Factor from murine submaxillary g

供应商      上海极威生物科技有限公司

表皮生长因子 来源于小鼠颌下腺      

suitable for cell culture

· 产品编号：E4127

· 中文名称：表皮生长因子 来源于小鼠颌下腺

· 英文名称：Epidermal Growth Factor from murine submaxillary gland

· 英文别名:EGF Epidermal cell growth factor

· CAS号：62229-50-9

· 保存温度：2-8 °C

· EC号：263-468-7

· MDL号：MFCD01634807

订货信息：

产品规格价格(RMB)

· E4127-0.1MG1,838.07元

· E4127-5X0.1MG7,376.85元

注：此价格仅供参考，请以销售价格为准，优惠价请电询。

性能描述

Analysis Note

The biological activity is measured in a proliferation assay using BALB/MK cells.

Biochem/physiol Actions

Qualified for use as a mitogen for a variety of epidermal ａnd epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular ａnd corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, ａnd SV40-3T3 cells.

Preparation Note

Purified by gel filtration.

Physical form

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

General description

Epidermal Growth Factor (EGF) is a 6 kDa polypeptide discovered by Cohen ａnd Levi -Montalcini ａnd isolated from mouse submaxillary glands. EGF is mitogenic for a variety of epidermal ａnd epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular ａnd corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa ａnd SV40-3T3 cells. In tissue cultures EGF can act to reduce or eliminate the requirement for serum ａnd is often used in conjunction with other media additives ａnd hormones, such as Insulin (Product No. I1882), Transferrin (Product No. T 5391), ａnd Prostaglandin E1 (Product No. P7527). Cellular metabolic effects of EGF include stimulation of ion fluxes, glucose transport, glycolysis, ａnd synthesis of DNA, RNA ａnd proteins.

Human EGF was originally isolated from human urine as β-Urogastrone, an inhibitor of gastric acid secretion. Mouse ａnd human EGF are 70% homologous in their sequence of 53 amino acids, act upon the same EGF receptor, elicit nearly identical biological effects ａnd are highly inter-species cross-reactive.

EGF is structurally homologous to human Transforming Growth Factor-α (Product Nos. T7533 ａnd T2035), which exerts its actions through EGF receptors. EGF is also homologous to a sequence contained in a 19 kDa protein of Vaccinia virus, which appears to utilize the EGF receptor to gain entry into cells. The EGF receptor is a 170 kDa glycoprotein having EGF-activated protein tyrosine kinase activity. Platelet-Derived Growth Factor(PDGF, Product No. P8147) transmodulates the EGF receptor by reduc ing both its EGF affinity ａnd its kinase activity.

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