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PeprotechRecombinant Human BMP-2细胞因子价格
点击次数：252发布时间：2016/1/14 9:06:10
更新日期：2022/5/31 10:15:44
所 在 地：中国大陆
产品型号：120-02
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详细内容
产品编号:
120-02
别名:
Bone Morphogenetic Protein-2, BMP-2A
描述:
BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone ａnd cartilage formation in association with osteoconductive carriers such as collagen ａnd synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, ａnd is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate ovary ａnd small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, ａnd a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) ａnd the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
氨基酸序列:
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
交叉反应:
Cow, Dog, Monkey, Mouse, Rabbit, Rat, Human, Gelatin Microparticles, N/A
研究领域:
原产国:
USA
仅用于研究。不适用于诊断或治疗。
