产品展示
Recombinant Murine IGF-1 Peprotech原装进口
点击次数：260发布时间：2016/1/14 9:40:52
更新日期：2022/5/31 10:15:44
所 在 地：中国大陆
产品型号：250-19
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详细内容
产品编号:
250-19
别名:
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
描述:
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation ａnd survival of various cell types, including muscle, bone, ａnd cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin ａnd relaxin. The IGFs are similar to insulin by structure ａnd function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I ａnd IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal ａnd C-terminal propeptide regions. Recombinant Murine IGF-I is a 7.6 kDa globular protein containing amino acids including 3 intra-molecular disulfide bonds.
氨基酸序列:
GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 was determined a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
交叉反应:
Rat, Mouse
研究领域:
原产国:
USA
仅用于研究。不适用于诊断或治疗。
