产品展示
Recombinant Human IL-4*新报价
点击次数：480发布时间：2016/1/14 10:07:44
更新日期：2022/5/31 10:15:44
所 在 地：中国大陆
产品型号：200-04
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详细内容
产品编号:
200-04
别名:
BCGF, BCDF, B cell stimulating factor (BSF-1)
描述:
IL-4 is a pleiotropic cytokine that regulates diverse T ａnd B cell responses including cell proliferation, survival ａnd gene expression. Produced by mast cells, T cells ａnd bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, ａnd IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 ａnd IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production ａnd allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
氨基酸序列:
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106units/mg.
交叉反应:
Human, Bacteria, Rat, Mouse, Leech
研究领域:
原产国:
USA
仅用于研究。不适用于诊断或治疗。
