产品展示
Recombinant Human IL-12Peprotech现货
点击次数：455发布时间：2016/1/14 10:37:30
更新日期：2022/5/31 10:15:44
所 在 地：中国大陆
产品型号：200-12
优质供应
详细内容
产品编号:
200-12
别名:
NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, IL-12p70
描述:
IL-12 is a potent regulator of cell-mediated immune responses ａnd it induces IFN-γ production by NK ａnd T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes ａnd connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth ａnd activity of activated NK, CD4+ ａnd CD8+ cells, ａnd induces the development of IFN-γ-producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) ａnd 40 kDa (p40) subunits (503 total amino acid residues).
氨基酸序列:
p35 Subunit: RNLPVA TPDPGMFPCL HHSQNLLRAV SNMLQKARQT LEFYPCTSEE IDHEDITKDK TSTVEACLPL ELTKNESCLN SRETSFITNG SCLASRKTSF MMALCLSSIY EDLKMYQVEF KTMNAKLLMD PKRQIFLDQN MLAVIDELMQ ALNFNSETVP QKSSLEEPDF YKTKIKLCIL LHAFRIRAVT IDRVMSYLNA S
p40 Subunit: IWELKK DVYVVELDWY PDAPGEMVVL TCDTPEEDGI TWTLDQSSEV LGSGKTLTIQ VKEFGDAGQY TCHKGGEVLS HSLLLLHKKE DGIWSTDILK DQKEPKNKTF LRCEAKNYSG RFTCWWLTTI STDLTFSVKS SRGSSDPQGV TCGAATLSAE RVRGDNKEYE YSVECQEDSA CPAAEESLPI EVMVDAVHKL KYENYTSSFF IRDIIKPDPP KNLQLKPLKN SRQVEVSWEY PDTWSTPHSY FSLTFCVQVQ GKSKREKKDR VFTDKTSATV ICRKNASISV RAQDRYYSSS WSEWASVPCS
来源:
CHO cells
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 was determined by the induction of IFN-γ from NK cells co-stimulated with IL-18 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.
交叉反应:
Bacteria, Monkey, Mouse, Human, Leech, Human + Mouse
研究领域:
原产国:
USA
仅用于研究。不适用于诊断或治疗。
