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Recombinant Murine TNF-a Peprotech*新报价
点击次数：531发布时间：2016/1/14 10:51:16
更新日期：2022/5/31 10:15:44
所 在 地：中国大陆
产品型号：315-01a
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详细内容
产品编号:
315-01A
别名:
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
描述:
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells ａnd fibroblasts. It belongs to the TNF family of ligands ａnd signals through two receptors, TNFR1 ａnd TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells ａnd is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, ａnd diabetes. Recombinant Murine TNF-α is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
氨基酸序列:
MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
交叉反应:
Monkey, Rat, Mouse, Human, Mouse + Chicken, Cow, Mouse + Bacteria, Human + Mouse
研究领域:
原产国:
USA
仅用于研究。不适用于诊断或治疗。
