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技术文章
AAV病毒载体的选择策略
点击次数:258 发布时间:2024/5/23 17:13:34
AAV病毒简介
rAAV血清型的选择
血清型 | 组织嗜性 | 推荐星 |
AAV1 | Smooth muscle, CNS, lung, retina, pancreas, heart, liver | ★ |
AAV2 | Smooth muscle, CNS, liver, kidney, retina | ★★★ |
AAV3 | Smooth muscle, liver, lung | ★ |
AAV4 | CNS, retina, lung, kidney | ★ |
AAV5 | Smooth muscle, CNS, lung, retina | ★★★ |
AAV6 | Smooth muscle, heart, lung, adipose, liver | ★★★ |
AAV6.2 | lung, liver | ★★ |
AAV7 | Smooth muscle, retina, CNS, liver | ★★ |
AAV8 | Smooth muscle, CNS, retina, liver, pancreas, heart, kidney, adipose | ★★★★ |
AAV9 | Smooth muscle, lung, liver, heart, pancreas, CNS, retina, testes, kidney | ★★★★★ |
AAVrh10 | Smooth muscle, lung, liver, heart, pancreas, CNS, retina, kidney | ★★★★ |
AAV-DJ | Liver, heart, kidney, spleen | ★★★ |
AAV-DJ/8 | Liver, brain | ★ |
AAV-PHP.eB | CNS | ★★★★★ |
AAV-PHP.S | PNS | ★★ |
AAV2-retro | Spinal nerves | ★★ |
AAV2-QuadYF | Endothelial cell | ★★ |
AAV2.7m8 | Retinal cells (when injected into vitreous humor), inner ear cochlear hair cells (when injected into the semicircular canal). | ★★★ |
原创作者:上海美轩生物科技有限公司