目市面上的卵清蛋白（OVA）通常含义较高水平的内毒素（脂多糖/LPS），内毒素在炎症反应的步的体外试验中可以完全激活内皮细胞。LPS是一种强有力的多效性炎症因子，因此，LPS污染可能会导致免疫实验的研究假阳性结果。药物静脉给药的阈值LPS水平设置为5EU/kg体重。

为了满足基于卵清蛋白（OVA）的体内（如注射、雾化）和体外（如增殖试验）研究的确切要求，艾美捷卵清蛋白(OVA)，特别纯净——EndoGrade 卵清蛋白（OVA），保证内毒素水平（LPS）＜0.1 EU/mg。

艾美捷卵清蛋白(OVA)相关参数： 

Source egg white

Also known as Plakalbumin, allergen Gal d 2, Gal d II

The preparation is made from egg white through ion exchange, crystallization ａnd pH 4.6

Purity (SDS-PAGE)>98%

Endotoxin level<0.1 EU/mg

Microbial contamination<10 cfu/mg

Molecular weight~45kDa

Extinction coefficient 0.7 ml mg-1 cm-1

Maximum solubility in water 20 mg/m

CAS No.: 9006-59-1

Product form: freeze-drying, without salt

Storage conditions/shelf life Freeze dried EndoGrade ovalbumin is stored at 2-8 ° C until the specified expiry date. If stored at - 20 ° C, restructure EndoGrade? Ovalbumin can be stable for 6 months

艾美捷卵清蛋白(OVA)相关研究：

LET0027 EndoGrade卵清蛋白[UNK]内毒素水平：<0.1 EU/mg 25 mg

LET0028内源性“卵蛋白内毒素”水平：<0.1 EU/mg 100 mg

LET0029 EndoGrade卵清蛋白[UNK]内毒素水平：<0.1 EU/mg 1000 mg

卵清蛋白(OVA)卵清蛋白(OVA)部分引文赏析：

1、Barr AM, Silva A, Prato S, Belz GT, Maraskovsky E, Baz Morelli A. Therapeutic ISCOMATRIX adjuvant vaccine elicits effective anti-tumor immunity in the TRAMP-C1 mouse model of prostate cancer. Cancer Immunol Immunother. 2020 Oct;69(10):1959-1972. doi: 10.1007/s00262-020-02597-6.

2、Farazuddin M, Goel RR, Kline NJ, Landers JJ, O＇Konek JJ, Baker JR Jr. Nanoemulsion Adjuvant Augments Retinaldehyde Dehydrogenase Activity in Dendritic Cells via MyD88 Pathway. Front Immunol. 2019 May 8;10:916. doi: 10.3389/fimmu.2019.00916.

3、Olson WJ, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, Baier G, Hermann-Kleiter N. Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21. Cell Rep. 2019 Sep 10;28(11):2878-2891.e5. doi: 10.1016/j.celrep.2019.08.024.

来源：https://www.amyjet.com/products/LET0027.shtml