链亲和素ZAP是链亲和素和核糖体失活蛋白saporin的化学偶联物。它将生物素化物质转化为目标毒素。

Advanced Targeting Systems/ATSbio艾美捷这些试剂盒将生物素化物质转化为靶向毒素，并允许用户评估试剂与受体结合后内化的能力。

目标推荐      体内推荐     体外 

生物素化肽   链亲和素ZAP肽试剂盒（KIT 27-B）  生物素Z肽内化试剂盒（KIT -27-ZB）

生物素化抗体  Streptavidin ZAP抗体试剂盒（KIT -27-A）山羊、人、小鼠、大鼠或兔生物素Z抗体内化试剂盒（KIT -27-Z）山羊、人、鼠、鼠或兔

其他生物素化材料 Streptavidin ZAP试剂盒（KIT 27-S）Streptavidin ZAPKIT（KIT-27-S）

Advanced Targeting Systems/ATSbio 艾美捷其它热门ZAP研究：

IT-27 Streptavidin-ZAP 生物素化靶向剂

IT-51 Fab-ZAP human 人单克隆抗体

IT-48 Fab-ZAP mouse 小鼠单克隆抗体

IT-65 FabFc-ZAP human 人IgG

IT-55 Fab-ZAP rat 大鼠IgG

Advanced Targeting Systems/ATSbio艾美捷Streptavidin-ZAP相关文献：

CD3e-immunotoxin spares CD62Llo Tregs ａnd reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S (2022) CD3e-immunotoxin spares CD62Llo Tregs ａnd reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells. Front Immunol 13:1011190. doi: 10.3389/fimmu.2022.1011190

Objective: To use a new murine testing model to demonstrate a substantial enrichment of tissue-resident Foxp3+ Tregs following CD3e-IT treatment.

Summary: The multi-organ pharmacodynamics of CD3e-IT ａnd potential treatment resistance mechanisms identified in this study may generate new opportunities to further improve this promising treatment.

Usage: Male C57BL/6J mice were injected into retro-orbital sinus with 15 μg S-CD3e-IT (Biotinylated Anti-CD3 mixed with Streptavidin-ZAP in sterile 200 μl PBS twice a day for four consecutive days.

Related Products: Streptavidin-ZAP (Cat. #IT-27)

In vivo visualization ａnd molecular targeting of the cardiac conduction system

Goodyer WR, Beyersdorf BM, Duan L, van den Berg NS, Mantri S, Galdos FX, Puluca N, Buikema JW, Lee S, Salmi D, Robinson ER, Rogalla S, Cogan DP, Khosla C, Rosenthal EL, Wu SM (2022) In vivo visualization ａnd molecular targeting of the cardiac conduction system. J Clin Invest e156955. doi: 10.1172/jci156955

Objective: To engineer targeted antibody conjugates directed against the cardiac conduction system (CCS) to allow visualization of the CCS in vivo.

Summary: Accidental injury to the CCS, a specialized set of cells embedded within the heart ａnd indistinguishable from the surrounding heart muscle tissue, is a major complication in cardiac surgeries. They generated a fully human monoclonal Fab (hCNTN2) that targets the CCS with high specificity.

Usage: Streptavidin-ZAP was reacted with biotinylated hCNTN2 Fab to create hCNTN2-SAP. 100 ug of either hCNTN2-SAP ａnd control-SAP were injected into wild-type mice with a single tail-vein injection ａnd hearts were harvested after 2 days.

Related Products: Streptavidin-ZAP (Cat. #IT-27)

Advanced Targeting Systems(ATSbio)主要研究域包含神经靶向毒素，神经生物学研究方面的抗体/蛋白，靶向剂内化水平检测工具等。艾美捷科技是ATSbio的中国代理商，为科研工作者提供优质的产品与服务。

来源：https://www.amyjet.com/brand/Advanced-Targeting-Systems.shtml