Advanced Targeting Systems/ATSbio艾美捷192 IgG SAP是小鼠抗大鼠p75NTR单克隆抗体和核糖体失活蛋白saporin的化学缀合物。它特别地消除了表达p75NTR的细胞，也被称为低亲和力神经生长因子受体。

Advanced Targeting Systems/ATSbio 艾美捷其它高引文数量研究：

IT-14 CTB-SAP 靶向表达GM1受体的细胞

IT-16 mu p75-SAP 靶向表达小鼠p75NTR的细胞

IT-03 Anti-DBH-SAP 靶向表达大鼠多巴胺β羟化酶的细胞

IT-10 IB4-SAP 靶向表达α-D-吡喃半乳糖苷残基的细胞

Advanced Targeting Systems/ATSbio艾美捷192 IgG SAP相关文献：

Neurotoxic effects, mechanisms, ａnd outcome of 192 IgG-Saporin lesions.

Petrosini L, De Bartolo P, Cutuli D (2021) Neurotoxic effects, mechanisms, ａnd outcome of 192 IgG-Saporin lesions. RM Kostrzewa (Ed.): Handbook of Neurotoxicity . Springer, Cham doi: 10.1007/978-3-030-71519-9_79-1

Summary: 192-IgG-saporin selectively destroys basal forebrain cholinergic neurons that provide cholinergic input to the hippocampus, entire cortical mantle, amygdala, ａnd olfactory bulb. Immunotoxic lesions by 192-IgG-saporin represent a valid animal model of Alzheimer’s disease, given the degeneration of basal cholinergic system present in this pathology. The selective lesioning of cholinergic innervation by means of 192-IgG-saporin (injected i.p. or i.c.v.) is able to interfere with experience-dependent plasticity.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat.

Vierck C, Yezierski R, Wiley R (2016) Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat. Neuroscience 319:23-34. doi: 10.1016/j.neuroscience.2016.01.038

Objective: There is a large amount of research on the involvement of cholinergic mechanisms on spinal transmission of pain signals, indicating that cholinergic agonists can attenuate this kind of pain. In contrast, some studies have shown affective reactions to pain are suppressed by cholinergic antagonists. The authors investigated the disagreement between reflexive ａnd affective reactions.

Summary: Lesioned rats displayed decreased escape from thermal stimulation, as well as loss of the normal hyperalgesic effect of sound stress. Results indicate that the basal forebrain cholinergic system plays a role in central processing of pain.

Usage: Administration of 192-IgG-SAP with a 4-μg injection into the left lateral ventricle of rats. Animals were tested in temperature escape ａnd sound stress models.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Advanced Targeting Systems(ATSbio)主要研究域包含神经靶向毒素，神经生物学研究方面的抗体/蛋白，靶向剂内化水平检测工具等。艾美捷科技是ATSbio的中国代理商，为科研工作者提供优质的产品与服务。

来源：https://www.amyjet.com/brand/Advanced-Targeting-Systems.shtml