CATALOGUE NUMBER

PRO-553

SYNONYMS

Beta-2-microglobulin, B2M.

INTRODUCTION

Beta 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2 microglobulin associates with class I-like molecules such as CD1 ａnd Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of Beta 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I.

Beta 2-microglobulin is present in small amounts in serum, csf, ａnd urine of normal people, ａnd to a much greater degree in the urine ａnd plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors ａnd autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma ａnd lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces.

DESCRIPTION

Human Beta-2 Microglobulin produced in Human urine from patients with tubular proteinuria having a molecular mass of 12KDa.

SOURCE

Human urine from patients with tubular proteinuria.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

Lyophilized from 0.02M NH4HCO3.

SOLUBILITY

It is recommended to reconstitute the lyophilized HuB2M in phosphate buffer pH > 7.0 containing 0.15M NaCl.

艾美捷灭瘟素S Blasticidin S中文说明书：

艾美捷灭瘟素S Blasticidin S 是一种肽基核苷抗生素。它先是从S. griseochromogenes中分离出来的。五水合物形式的结构是使用衍射仪数据确定的，与抗生素阿米西丁类似，亲水基团和疏水基团位于分子的两侧。它是使用全合成创建的。

艾美捷灭瘟素S Blasticidin S（盐酸盐）用于研究选择用杀稻瘟素抗性基因bsr转染的哺乳动物细胞。不供人类或兽医使用。

艾美捷灭瘟素S Blasticidin S化学性质：

正式名称：4-[[(3S)-3-氨基-5- [(氨基亚氨基甲基)甲基氨基]-1-氧代戊基]氨基]-1- (4-氨基-2-氧代-1(2H)-嘧啶基)- 1,2,3,4-四脱氧-β-D-赤型-己-2-烯吡喃糖醛酸，单盐酸盐

CAS 编号：3513-03-9

分子式：C 17 H 26 N 8 O 5 • HCl

配方重量：458.9

纯度：≥95%

公式：结晶固体

溶解度：H2O/HAc (50:50)：10mg/mL

起源：细菌/灰色链霉菌

贮存：-20°C

船运：美国大陆的室温；其他地方可能会有所不同

稳定：≥ 4 年

来源：https://www.amyjet.com/products/14499-10.shtml