白细胞介素 5 (IL-5, IL5) 由活化的 CD4+ TH2 型细胞、NK 细胞、肥大细胞和 B 细胞产生。它门控制嗜酸性粒细胞的产生、激活和定位。

艾美捷抗人IL-5单抗5A10：

这种单克隆抗体能够在 ELISA 和 ELISpot 等免疫分析中灵敏且特异地检测人 IL-5。

推荐 5A10 作为 ELISA 和 ELISpot 中的检测抗体与捕获抗体 TRFK5 结合使用。

艾美捷抗人IL-5单抗5A10非人类灵长类动物交叉反应：

与 NHP 反应的系统要么基于交叉反应的人类试剂盒，要么基于门开发的猴子试剂盒 (NHP)。

交叉反应性验证测试已由 Mabtech 和/或其他人在 ELISpot 和/或 ELISA 中进行。交叉反应证据较少的测定被定义为适应症。

艾美捷抗人IL-5单抗5A10文献参考：

Minang, J. T., et al. (2008). ELISpot displays a better detection over ELISA of T helper (Th) 2-type cytokine-production by ex vivo-stimulated antigen-specific T cells from human peripheral blood. Immunological investigations.

Mola, P. W., et al. (1999). Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure ａnd treatment. Infection ａnd immunity.

Schulten, V., et al. (2013). Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proceedings of the National Academy of Sciences of the United States of America.

Seumois, G., et al. (2016). Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. Journal of immunology.

Shastri, M. D., et al. (2015). Opposing Effects of Low Molecular Weight Heparins on the Release of Inflammatory Cytokines from Peripheral Blood Mononuclear Cells of Asthmatics. PLoS ONE.

来源：https://www.amyjet.com/products/3490-6-1000.shtml