产品货号XY0016
产品名称BRCA1抗体
中文名称乳腺癌易感基因1抗体
蛋白名Breast cancer type 1 susceptibility protein
别称IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53
BRCA1抗体
免疫原重组蛋白（来源于大肠杆菌）
来源兔
特异性抗人、大鼠、小鼠
克隆类型多克隆
应用IH(P)免疫组化(石蜡)；IH(F)免疫组化(冰冻)；IC细胞免疫化学；WB免疫印迹
研究领域肿瘤，细胞生物，表观遗传学
成分200μg/ml亲和纯化抗体，0.01M PBS，30%甘油。
保存条件连续使用时4°C存储，保质期六个月；长期存储时建议分装为10ul以上小包装-20°C存储，并避免反复冻融，保质期一年。
背景资料This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, ａnd it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
 参考效价：

抗体保存得当与否直接决定了抗体的活性和使用效果。如果抗体保存得当，大部分抗体活性都可以维持数月甚至数年。请按照说明书或者抗体标签上推荐的保存条件正确保存抗体！无论是保存还是运输，绝对避免反复冻融抗体！

1.拿到抗体后请务必在1000-3000转离心1-2分钟后再打开管盖进行分装和保存！（由于运输过程中反复颠簸，管内微量抗体容易聚集在管盖处，一旦直接打开容易流失抗体。请放心抗体出厂时保证已装入足量。）

2.对于大部分抗体，比较合适的保存方式是分装后保存在-20℃冰箱。

◇分装可以程度降低反复冻融对抗体活性的损害，BRCA1抗体同时也降低了多次从同一管中吸取抗体造成污染的可能性。

◇分装的量以一次实验用完为好，但建议*少不要少于10μL每份。分装体积越小，抗体浓度可能会受到蒸发以及管壁吸附的影响，同时分装次数越多移液吸头吸附的抗体也越多，可能会误认为抗体没有足量装入。（用无菌的进口0.2ML离心管来分装抗体，国产的小管一般没有经过很好的硅化处理，容易吸附抗体蛋白，影响抗体活性。）

◇分装时请将无菌的微量移液器吸头先插入管底部反复吹打几次后再吸出抗体，BRCA1抗体以便抗体有效成分与抗体保护剂充分混匀。

◇复融后的分装抗体如果一次用不完，请将剩余母液保存在4℃冰箱，避免再冻起来！

◇绝对避免将抗体保存在自动除霜冰箱的冷藏室中。尽量将抗体保存在手动除霜冰箱里面，而不是在冰箱门上。

3.大部分抗体收到后4℃短暂保存1-2周对抗体活性是基本没有影响的。如果抗体很快（1-2周内）就能使用完，推荐在4℃保存，避免反复冻融对抗体活性的损害。如果要长期保存则分装后-20℃保存。

4.即用型抗体请务必保存在4℃冰箱，一定不能冷冻保存。

5.特殊抗体的保存：

◇酶联抗体：一般保存在4℃，尽量避免冷冻起来。否则可能会导致酶活力的下降或者丧失。

◇偶联抗体：所有偶联抗体需要4℃避光保存。尤其是荧光标记抗体，对光极为敏感，因此所有实验阶段也是要避光操作的。

 XY161Mu01N-乙酰α-D-氨基葡萄糖苷酶(NAGLU)多克隆抗体Polyclonal Antibody to N-Acetyl Alpha-D-Glucosaminidase (NAGLU)Mus musculus (Mouse)

XY633Mu01血小板衍生生长因子BB(PDGFBB)多克隆抗体Polyclonal Antibody to Platelet Derived Growth Factor BB (PDGFBB)Mus musculus (Mouse)

XY749Mu01过氧化还原酶1(PRDX1)多克隆抗体Polyclonal Antibody to Peroxiredoxin 1 (PRDX1)Mus musculus (Mouse)

XY950Mu01孕烷X受体(PXR)多克隆抗体Polyclonal Antibody to Pregnane X Receptor (PXR)Mus musculus (Mouse)

XY769Mu01核糖体结合糖蛋白Ⅰ(RPN1)多克隆抗体Polyclonal Antibody to Ribophorin I (RPN1)Mus musculus (Mouse)

XY050Mu01线粒体转录因子A(TFAM)多克隆抗体Polyclonal Antibody to Transcription Factor A, Mitochondrial (TFAM)Mus musculus (Mouse)

XY552Mu01WAP四二硫化物核心域蛋白5(WFDC5)多克隆抗体Polyclonal Antibody to WAP Four Disulfide Core Domain Protein 5 (WFDC5)Mus musculus (Mouse)

XY348Po01组织蛋白酶A(CTSA)多克隆抗体Polyclonal Antibody to Cathepsin A (CTSA)Sus scrofa; Porcine (Pig)

XY878Po01凝血因子Ⅷ(F8)多克隆抗体Polyclonal Antibody to Coagulation Factor VIII (F8)Sus scrofa; Porcine (Pig)

XY388Ra01补体成分5a(C5a)多克隆抗体Polyclonal Antibody to Complement Component 5a (C5a)Rattus norvegicus (Rat)

XY388Ra02补体成分5a(C5a)多克隆抗体Polyclonal Antibody to Complement Component 5a (C5a)Rattus norvegicus (Rat)

XY902Ra01心肌钙黏蛋白(CDHH)多克隆抗体Polyclonal Antibody to Cadherin, Heart (CDHH)Rattus norvegicus (Rat)