1，5-二咖啡酰奎宁酸19870-46-3产品规格有哪些？ http://www.app17.com/c116106/products/d10821609.html
 1，5-二咖啡酰奎宁酸19870-46-3日头条 中文名称:1,3-二咖啡酰奎宁酸中文同义词:1,3-二咖啡酰奎宁酸19870-46-3;1,3-二咖啡酰奎宁酸;1,3-二咖啡酰奎宁酸,对照品,;洋蓟素、朝蓟素
英文名称:CYNARIN英文同义词:1,3-Dicaffeoylquinicacid;(1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylicacid;DicaffeoylquinicAcid,1,5-;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicacid;1,5-di-O-Caffeoylquinicacid;Cyclohexanecarboxylicacid,1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-,(1S,3R,4R,5R)-;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci
CAS号:19870-46-3
分子式:C25H24O12
分子量:516.45EINECS号:214-655-7
1，5-二咖啡酰奎宁酸19870-46-3日头条相关类别:其他生化试剂;标准品;对照品,标准品;标准品-中药标准品;标准品，对照品;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextractMol文件:19870-46-3.mol1,3-二咖啡酰奎宁酸性质沸点819.9±65.0°C(Predicted)密度1?+-.0.1g/cm3(Predicted)储存条件2-8°C溶解度soluble5mg/mL,clear,colorlesstolightyellow形态neat酸度系数(pKa)2.50±0.50(Predicted)颜色whitetooff-white1,3-二咖啡酰奎宁酸
用途与合成方法生物活性1,3-Dicaffeoylquinicacid是咖啡酰奎宁酸衍生物，具有抗氧化活性和自由基清除活性。
靶点AktPI3K
体外研究1,3-DicaffeoylquinicacChemicalbookidshowsincreasedneuronalcellviabilityagainstAβ(42)toxicityinaconcentration-dependentmannerinneurons.1,3-Dicaffeoylquinicacidactivatesbothphosphoinositide3-kinase(PI3K)/Aktandextracellularregulatedproteinkinase1/2(Erk1/2)withstimulatingtheirupstreamtyrosinekinaseA(TrkA).1,3-Dicaffeoylquinicacid＇santi-apoptoticpotentialisrelatedtotheenhancedinactivatingphosphorylationofglycogensynthasekinase3β(GSK3β)andthemodulationofexpressionofapoptosis-relatedproteinBcl-2/Bax.1,3-Dicaffeoylquinicacid(10μM,20μM,50μM,and100μM)significantlyincreasescellviablitybeforeOGD/reperfusion,andpreventsthedepletionofGSHunderOGD/reperfusioninsult.1,3-DicaffeoylquinicacidinducesnucleartranslocationofNrf2inOGD/reperfusiontreatedastrocytes,andinducesincreasedGCLactivity,andtheeffectislostinNrf2siRNA-transfectedcells.
体内研究1,3-Dicaffeoylquinicacid(32.0mg/kg,p.o.)and1-O-ABLareabsorbedveryquicklyinWistarrats.Themaximumplasmaconcentrationsfor1,3-Dicaffeoylquinicacidand1-O-ABLare44.5±7.1and19.1±6.9ng/mL,respectively.
1，5-二咖啡酰奎宁酸19870-46-3日头条
化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于洋蓟叶，朝鲜蓟，森林千里光全草、金银花。用途1,5-O-二咖啡酰奎宁酸具有护肝，降低胆醇的作用。用途用于含量测定/鉴定/药理实验等。药理药效:具有氧化、抗炎、抗病毒、抗纤维化、抑制平滑肌收缩、降血脂等诸多作用。安全信息

原创作者：上海依赫生物科技有限公司