二甲基姜黄素52328-98-0 日发布 中文名称:二甲基姜黄素中文同义词:ASC-J9生产厂家;二甲基姜黄素;四甲基姜黄素;二甲基姜黄素,≥95%
英文名称:ASC-J9英文同义词:1,4,6-Heptatrien-3-one,1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one(ASC-J9);(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one;Dimethylcurcumin;GO-Y025;Dimethylcurcumin,≥95%;Dimethylcurcumin【(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one】
CAS号:52328-98-0
分子式:C23H24O6
分子量:396.43EINECS号:2017-001-1
二甲基姜黄素52328-98-0 日发布 相关类别:分析试剂标准品;标准品;对照品;中药对照品;植物提取物;对照品-中药对照品;标准品-中药标准品Mol文件:52328-98-0.mol二甲基姜黄素性质熔点129-130℃沸点588.6±50.0°C(Predicted)密度1.191酸度系数(pKa)8.34±0.60(Predicted)二甲基姜黄素用途与合成方法生物活性Dimethylcurcumin(ASC-J9,Dimethylcurcumin,GO-Y025)是一种androgenreceptor(AR)降解促进剂，可通过降解全长和剪接变异体的雄激素受体来抑制去势抵抗性列腺癌的生长。
靶点TargetValueAR()体外研究Dimethylcurcumin(ASC-J9)isabletodegradefARandAR3inadose-dependentmannerinvarioushumanPCacells.Dimethylcurcumin(ASC-J9)canalsoeffectivelysuppressAR-targetedgenesinCWR22Rv1-fARKDcells.DimethylcurcumiChemicalbookn(ASC-J9)(5or10µM)significantlysuppressestheDHT-inducedcellgrowthinallthreePCacelllines.Dimethylcurcumin(ASC-J9)suppressesAR-targetedgenesandcellgrowthbydegradationoffARandecicAR3inC81andC4-2cells.Dimethylcurcumin(ASC-J9)selectivelypromotesARdegradationbydisruptingtheinteractionbetweenARandARcoregulators.ASC-J9reducestheARaggregatedAR-112Qincells.Dimethylcurcumin(ASC-J9)suppressestheaggregationofAR-112QinSBMAPC12/AR-112Qcells
.体内研究Dimethylcurcumin(ASC-J9)(75mg/kg,i.p.)degradesbothfARandAR3inthexenograftedtumorsinvivo,andSC-J9-treatedtumorshassignificantlydecreasedKi67-positivecells.Dimethylcurcumin(ASC-J9)(50mg/kgevery48h,i.p.)substantiallyamelioratestheSBMAsymptomsinAR-97Qmice,andamelioratesneuromuscularpathologicalfindings.TheDimethylcurcumin(ASC-J9)-treatedSBMAmicehaverelativelynormalserumtestosteroneconcentrations.ASC-J9-treatedmiceshowsignificantlysmallerprostatetumorsizeswhencomparedwiththosereceivingclassicADT/castrationwithlittleserumandrogen.化学性质可溶于甲醇、乙醇、DMSO等有机溶剂。