血根碱；氯化血根碱2447-54-3  研发结果 中文名称:血根碱中文同义词:血根碱;血根碱(标准品);血根鹼;SANGUINARINE血根碱;SANGUINARINE血根碱标准品;血根碱.博落回提取物;假白屈菜季铵碱;血根碱40%英文名称:SANGUINARINE英文同义词:13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium;C06162;PSEUDOCHELERYTHRINE;SANGUINARIN;SANGUINARINE;3)-benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(;dimethylenedioxybenzphenanthridine;SANGUINARINECHLORIDEISOLATEDFROMMACLEAY
CAS号:2447-54-3
分子式:C20H14NO4+
分子量:332.33EINECS号:219-503-3
血根碱；氯化血根碱2447-54-3  研发结果相关类别:中药对照品;分析对照品;小分子抑制剂;对照品;小分子抑制剂，天然产物;植物提取物;标准品;对照品,标准品;医药原料;标准品-中药标准品;生物碱;标准品-中药标准品;分析试剂-标准品;分析试剂;标准品，对照品;其他原料;化工原料;分析试剂标准品;Alkaloids;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;naturalproduct;InhibitorsMol文件:2447-54-3.mol
血根碱性质熔点205-215°C
沸点483.53°C(roughestimate)
密度1.3463(roughestimate)折射率1.5180(estimate)
血根碱用途与合成方法阳离子抗菌剂血根碱(Sanguinarine，简称Sa)，是由美洲血根草(SanguinariaCanadensis)提取的一种阳离子抗菌剂，血根碱是属苯并菲啶类生物碱。血根碱有广泛的抗菌活性(包括嗜氧和厌氧细菌、致病和非致病口腔细菌)。血根碱对口腔组织(特别是牙菌斑)有直接性。血根碱牙膏和含血根碱的漱口液在市场上已销售多年，并进行了广泛的临床试验。
血根碱；氯化血根碱2447-54-3  研发结果牙膏研磨剂为磷酸二钙，锌盐为漱口液中的配料。图1为血根碱化学结构式临床研究结果表明，血根碱对口腔中大多数细菌有抑菌和杀菌作用，并有干扰细菌粘附于刚形成的牙膜上的作用。含血根碱提取物(SaE)/氯化锌的牙膏和漱口液的临床试验表明，用含质量分数为0.075%SaE、质量分数为2.0%或更多的氯化锌牙膏和含质量分数为0.03%SaE、质量分数为0.2%氯化锌漱口液进行试验，7位试验者牙菌斑全部减少，牙龈健康改善，其中3位经历6个月后见效。短期试验的效果还有待进一步证实。血根碱作用机理还需要进一步探讨。氯化锌和血根碱各自对复配物活性的贡献还不清楚，市售含血根碱的牙膏是含有阳离子抗菌剂和阴离子表面活性剂(月桂基硫酸酯钠盐)的配方，在该牙膏中血根碱(阳离子抗菌剂)仍然保持其抗菌活性，其原因还不清楚。以上信息由Chemicalbook彤彤编辑整理。
生物活性Sanguinarine(Sanguinarin)是一种来源于SanguinariaCanadensis的生物碱，可通过激活活性氧(ROS)的产生来刺激细胞凋亡。Sanguinarine诱导的细胞凋亡与JNK和NF-κB的活化有关。靶点ApoptoChemicalbooksis体外研究Sanguinarine(SANG)-inducedapoptosisisassociatedwiththeactivationofJNKandNF-κBsignalpathways.TodeterminetheeffectsofSanguinarineoncellviability,22B-cFluccellsarestimulatedwithdifferentconcentrationsofSanguinarinefor24h,andthenaCKK-8assayisperformed.ThetreatmentwithSanguinarinedecreasestheproliferationof22Bcellsinadose-dependentmanner.Meanwhile,thecytosolicextractsof22B-cFluccellstreatedwithdifferentdoseofSanguinarinearemeasuredtodetectcellularcaspase-3activityusingAc-DEVD-pNA,whichisavalidatedcaspase-3substrate.Theabsorbanceat450nmincreasesinadose-dependentmanner,indicatingincreasedcaspase-3activitystimulatedbySanguinarine.体内研究ToevaluatetheapoptosisinducedbySanguinarine(SANG)invivo,22B-cFluccellsareinoculatedsubcutaneouslyintooneflankofnudemiceandxenograftmodelsareallowedtoestablish.Micearetreatedintravenouslywith10mg/kgofSanguinarine.At24,48and72haftertreatment,bioluminescentimagingisperformedafteri.p.injectionofmicewith150mg/kgofD-luciferinsubstrate.Sanguinarinetreatmentinducesanobviousincreaseofluminescentsignalasearlyas48hafterinitialtreatment.Asustainedbioluminescentimaging(BLI)intensityincreasedisobservedthroughoutthecourseofexperiment.At72haftertreatment,thetumorsarecollectedandsubjectedtoTUNELstainingforevaluatingapoptosis.Comparedwiththecontroltumors,thegrouptreatedwithSanguinarineexhibitssignificantlymorecellapoptosis,indicatedbytheincreasedgreensignalsfromthesporadicapoptoticcells.化学性质溶于甲醇、乙醇溶液中，不溶于石油醚、来源于科植物博落回的带根全草。用途用于含量测定/鉴定/药理实验等。药理药效:具有抗菌、杀虫作用，改善肝功能、增强免疫力，有一定的抗肿瘤作用。