Aalto provides a comprehensive portfolio of products to a discerning Tier One client base worldwide. Quality is of the utmost importance to Aalto ａnd through our ISO quality assurance certification and processes we are dedicated to delivering the highest quality, most reliable end product to our customers. Our portfolio includes the following:
NEWS The IVD industry is moving towards nucleic acid based diagnostics for faster detection of infectious diseases. The challenge for laboratories is ϐinding effective ａnd affordable control technology to monitor processes from start to ϐinish, ａnd report patient results. Aalto Bio Reagents entered the molecular diagnostics market in 2015 with AaltoCC, our new range of external run controls designed to address the quality ａnd regulatory challenges fac ing molecular diagnos ti c s laboratories. The AaltoCC controls act like human patient samples ａnd are suitable for daily control of both the extraction ａnd ampliϐication processes. AaltoCC controls are supplied in kits of 10 vials (200ul or 1ml) ａnd will be available for the following targets : · Cytomegalovirus (plasma) · Chlamydia trachomatis (exudate) · Chlamydia trachomatis (urine) · Chlamydia trachomatis/Neisseria gonorrhoeae (exudate) · Chlamydia trachomatis/Neisseria gonorrhoeae (urine) · Epstein Barr Virus (plasma) · HSV-1 (CSF) · HSV-1 (plasma) · HSV-1/HSV-2 (CSF) · HSV-1/HSV-2 (plasma) · HSV-2 (CSF) · HSV-2 (plasma) · HSV-1/HSV-2/VZV (exudate) · Mycobacterium tuberculosis (sputum) · Mycobacterium tuberculosis INH resistant strains (sputum) · Mycobacterium tuberculosis RIF resistant strains (sputum) · Neisseria gonorrhoeae (exudate) · Neisseria gonorrhoeae (urine) · VZV (CSF) Under development · BK Virus (plasma) · JC Virus (plasma) · HPV (exudate) Molecular Molecular Diagnostics Controls Disease State Plasmas Antisera Infectious Disease Antigens Antibodies Proteins Tumour Markers Cardiac Markers Quality ISO 9001:2008 NSAI Certied Arboviruses Arthropod-borne viruses (arboviruses) are important causes of human disease nearly worldwide. In recent years the numbers of reported cases of Arbovirus such as Dengue, Chikungunya ａnd Zika virus has been increasing. These viruses are spread by the bite of an infected Aedes mosquito ａnd cannot be spread directly from person to person. Outbreaks of endemic mosquitoborne illnesses are common in the tropical ａnd subtropical climates of Australia, Asia, tropical Africa ａnd South America. Arboviruses, particularly Dengue, can be serious diseases with symptoms including high fever, headache, pain behind the eyes, joint pain, muscle ａnd bone pain ａnd rash. With Dengue, patients may experience mild bleeding (e.g. gums ａnd nose bleeds). The early clinical manifestations of Dengue, Chikungunya ａnd Zika virus are very similar so it is important to differentiate between the three in order to eliminate Dengue. NSAIDs can alleviate symptoms in Chikungunya ａnd Zika virus but should be avoided in patients with Dengue due to risk of haemorrhaging. Laboratory diagnosis is generally accomplished by testing serum or plasma to detect virus, viral nucleic acid, or virus-speciϐic immunoglobulin M ａnd neutralizing antibodies. Aalto Bio Reagents are now supplying a full range of Zika, Chikungunya ａnd Dengue virus antigens. These antigens can be used as components for development of diagnostic assays. Ÿ Recombinant Chikungunya E1 antigen, mutant Ÿ Recombinant Chikungunya E1 antigen, wild type Ÿ Recombinant Chikungunya E2 antigen Ÿ Recombinant Zika virus envelope antigen Ÿ Recombinant Zika virus NS1 antigen Ÿ Recombinant Dengue NS1 (types 1 – 4) Ÿ Recombinant Dengue envelope proteins (type 1 – 4) Please contact us for further information. Rebranding NEWS Monoclonal Antibodies Recombinant Antigens SERUM PROTEINS · CRP concentrate · ASO concentrate · RF concentrate MYELOMA PLASMA · IgG · IgM · IgA · IgE INFECTIOUS DISEASE STATE PLASMA · EBV IgG/IgM · Chlamydia pneumoniae IgG/IgA/IgM · Infectious mononucleosis · HAV IgM · Lyme IgG/IgM · Measles/Mumps/Rubella Negative · TORCH IgG/IgM · Syphilis/RPR · Chagas IgG/IgM · Dengue IgG/IgM · HBsAg ad ａnd ay · Anti-HBc (total ａnd IgM) · Anti-Leishmania · Anti-Parasitic THYROID FUNCTION · Anti-Thyroglobulin · Anti-Thyroid Peroxidase AUTOIMMUNITY AND ALLERGY · Anti-tissue Transglutaminase · Anti-Gliadin · Cardiolipin IgG/IgM/IgA · Myasthenia gravis · Allergen speciϐic IgE · Total IgE · Cag A protein of Helicobacter pylori · Carcinoembryonic Antigen · Chikungunya envelope NEW · CRP NEW · Cyclosporin A NEW · IGF-1 · Inϐluenza virus, types A ａnd B · Listeria monocytogenes · Neuron Speciϐic Enolase · Pregnancy Associated Plasma Protein A · Procalcitonin NEW · Sex Hormone Binding Globulin · Testosterone · Thyroid Stimulating Hormone · Troponin I · Aspergillus fumigatus · Bordetella pertussis · Borrelia afzelii · Borrelia garinii · Brucella abortus · Campylobacter jejuni · Chlamydia pneumoniae · Chlamydia trachomatis · Coxsackievirus NEW · Cytomegalovirus · Echinococcus granulosus NEW · Helicobacter pylori · Inϐluenza Type A ａnd B · Legionella pneumophila · Leishmania infantum · Leptospira biϐlexa · Measles (Rubeola) · Mumps · Mycoplasma pneumoniae · Parainϐluenza 1, 2 ａnd 3 · Respiratory Syncytial Virus · Rotavirus · Rubella · Tick-Borne Encephalitis · Toxoplasma gondii · Treponema pallidum · Varicella Zoster Virus · VZV Glycoprotein NEW · Yersinia enterocolitica YOPs NEW · Borrelia afzelii · Borrelia garinii · Borrelia burgdorferi sensu stricto · Borrelia spielmanii · Chikungunya E1 (wild type) NEW · Chikungunya E1 (A226V) NEW · Chikungunya E2 NEW · Dengue NS1 (types 1 – 4) · Dengue envelope protein (types 1 – 4) · Ebola Virus Disease NEW · Chlamydia trachomatis MOMP · Hepatitis B surface antigen – ad subtype · Hepatitis B surface antigen – ay subtype · Hepatitis B core · Parvovirus B19 NEW · Procalcitonin NEW · Type speciϐic gG1 protein of HSV-1 · Type speciϐic gG2 protein of HSV-2 NEW · Streptolysin O (SLO) · Treponema pallidum p15, p17 ａnd p47 · Treponema pallidum chimeric antigen NEW · Zika virus NS1 protein NEW · Zika virus envelope protein NEW Human Plasma Products Infectious Disease Rebranding Native Antigens NEWS NEWS NEW Product CA15-3 Polyclonal Antibodies · Alpha-1-microglobulin, afϐinity puriϐied (goat) NEW · Albumin, IgG fraction (goat) · Antithrombin III (goat) NEW · Apo A1 (goat) · Apo B (goat) · Apo E, IgG fraction (goat) · Beta-2-Microglobulin, IgG fraction (goat) · Creatine Kinase MM, afϐinity puriϐied (goat) · CRP, IgG fraction (goat) · Cystatin C, afϐinity puriϐied (goat) · Estradiol NEW · Ferritin (rabbit) NEW · Ferritin, IgG fraction (goat) · Fibrinogen (goat) NEW · Haemoglobin, afϐinity puriϐied (goat) · HBsAg, IgG fraction, afϐinity puriϐied (goat) · IgG (goat) · IgA (goat) · IgM (goat) · Lp(a) (goat) NEW · Myoglobin, IgG fraction (goat) NEW · Progesterone · 17-alpha-hydroxyprogesterone · Rotavirus, IgG fraction (rabbit) · Serum amyloid A (rabbit) NEW · Testosterone (rabbit) NEW SERUM PROTEINS · Albumin · Complement C3c · Complement C4c · C Reactive Protein (CRP) · D-Dimer · Fatty Acid Binding Protein · Beta-2-Glycoprotein-1 · Haptoglobin · IgA · IgE NEW · IgG Fc Fragment · IgM · Alpha-2-Macroglobulin DIABETES · Glycated Haemoglobin (HbA1c) · HbA1c solution, <3.5% · HbA1c solution, >25% NUTRITIONAL · Prealbumin · Retinol Binding Protein · Transferrin (carbohydrate deϐicient) · Transferrin (iron-free) · Transferrin (partially iron saturated) · Transferrin Receptor THYROID FUNCTION · Thyroglobulin (TG) · Thyroid Microsomal Antigen (TMA) · Thyroid Peroxidase (TPO) · Thyroxine Binding Globulin (TBG) · Thyroid Stimulating Hormone CANCER MARKERS · Alpha Ferotein · Beta-2-Microglobulin · CA 15-3 NEW · CA 19-9 · CA 125 · CK-MB, recombinant NEW · Ferritin (liver) · Ferritin light chain, recombinant NEW · Prostatic Speciϐic Antigen (PSA) · PSA-ACT Complex · Prostatic Acid Phosphatase (PAP) PITUITARY HORMONES · Follicle Stimulating Hormone · Recombinant Follicle Stimulating Hormone · Growth Hormone · Luteinizing Hormone · Prolactin · Prolactin, recombinant NEW · Thyroid Stimulating Hormone · Recombinant Thyroid Stimulating Hormone Tumour Markers Cardiac Markers Puriϐied Human Proteins Disease State Plasmas Antisera Infectious Disease Antigens Antibodies Proteins CA15-3 is used primarily as a marker for both early detection ａnd relapse of breast cancer. Increased levels are also associated with colon, lung ａnd hepatic tumours. It is becoming increasingly difϐicult to source the human raw material needed to produce native CA15-3. Aalto Bio are pleased to announce availability of partially puriϐied CA15-3, code BF 3315 produced from human ϐluids. The raw material will be available on a continuous basis so it eliminates the insecurity often associated with native material. The native CA15-3 complements our expanding range of cancer markers : Ÿ CA15-3, native Ÿ CA15-3, cell culture derived Molecular Diagnostics Controls Rebranding NEWS HIV-1 gp120env HIV-1 p24gag NEW Product Partially Puriϐied IgE Aalto Bio Reagents is pleased to announce availability of our partially puriϔied cell culture derived IgE (Aalto code AU 3296). IgE is a member of the immunoglobulin family of proteins that was ϐirst described in the 1960s. IgE, like all immunoglobulins, is produced by plasma cells in response to antigenic stimuli. IgE is unique however in certain structural aspects ａnd the role it plays in allergic diseases. Measurement of total serum IgE is often used as a tool in the diagnosis ａnd management of aic diseases such as asthma, hay fever, aic dermatitis ａnd urticaria. It has been used to distinguish aic from non-aic individuals presenting allergy-like symptoms. In addition, studies have also shown that increased levels of IgE in cord blood ａnd infants may be predictive of future aic tendencies. Normal levels of circulating IgE are extremely low in comparison to other immunoglobulins. Levels of IgE at birth are almost undetectable but increase in non-allergic adults. Elevated levels are commonly seen in cases of allergic diseases, parasitic infections, pulmonary aspergillosis, Wiskott-Aldrich Syndrome, ａnd myeloma. Myeloma IgE plasma has been the raw material of choice for many years for manufacturers of IgE control ａnd calibrators. Locating this natural product can be challenging ａnd often companies are forced to hold large volumes in stock or face potential out of stock situation. Compared to native myeloma plasma our cell culture derived IgE has the distinct advantage of always being available. The material is derived from a human myeloma cell line which means that lot to lot consistency is guaranteed without having to worry about relying on a donor ａnd all of the concerns that can accompany a natural product. Given an accurate forecast we can manufacture ａnd have available quantities ranging from a few mgs to multiple grams. Additionally the price per mg will not change depending on the titre, as would be the case when purchasing natural material by the ml. Please contact us today for a quotation. Aalto Bio provides a range of “do-it-yourself (DIY)” research assay protocols for detection of HIV-1 p24gag ａnd HIV-1 gp120env. These DIY ELISA assays are being widely used by AIDS research laboratories in Europe, the United States, Australia, Africa ａnd China for monitoring HIV-1 replication in a range of research applications. Demand for our afϐinity puriϐied anti-HIV-1 gp120env (code D7324) continues to grow among AIDS research laboratories. We have available a DIY ELISA protocol for detection of HIV-1 gp120env incorporating code D7324 as the capture antibody. The captured gp120 protein is recognised at a separate site by a second antibody that is, in turn, detected using a third, enzyme labelled, anti- antibody Three different DIY ELISA protocols are available with varying ranges of sensitivity for detection of HIV-1 p24gag. These assays use our afϐinity puriϐied anti-HIV-1 p24gag (code D7320), as the capture element. Our biotinylated conjugate or alkaline phosphatase conjugate of MAb to HIV-1 p24gag (respective codes BC1071-BIOT ａnd BC1071-AP) are used as label, together with appropriate detection systems. “Do-It-Yourself” ELISA Protocols for Detection of HIV-1 proteins For further Information please contact : Aalto Bio Reagents Ltd. Church Lane, Rathfarnham Village, D14 RK22, Ireland.
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