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mouse Anti-HDL antibody，高密度脂蛋白抗体
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上传时间：2017/5/19 22:20:29
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上 传 者：上海研晶生物科技有限公司
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产品编号Rs-506611R
英文名称HDL
中文名称高密度脂蛋白抗体
别 名APOA1; APOA2; APOC1; Apolipoprotein A C I; Apolipoprotein A I; Apolipoprotein A II; High Density Lipoprotein.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 免疫学 内分泌病
抗体来源mouse
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位分泌型蛋白
性 状Liquid
浓 度1mg/1ml
免 疫 原human HDL from plasma
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
HDL is a cholesterol carrier protein that acts as scavenger of tissue cholesterol. It is important in cholesterol efflux from tissues, ａnd involved in the return of cholesterol from the periphery to the liver for removal as bile acids.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, ａnd it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, ａnd with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008].
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues ａnd by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subunit:
Interacts with APOA1BP ａnd CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain ａnd albumin. Interacts with NDRG1.
Subcellular Location:
Secreted.
Tissue Specificity:
Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver ａnd small intestine. The oxidized form at Met-110 ａnd Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype ａnd exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I ａnd increased levels are seen with increasing severity of disease.
Post-translational modifications:
Palmitoylated.
Met-110 ａnd Met-136 are oxidized to methionine sulfoxides.
Phosphorylation sites are present in the extracellular medium.
Similarity:
Belongs to the apolipoprotein A1/A4/E family.
SWISS:
P02647
Gene ID:
335
Database links:
Entrez Gene: 335 Human
Entrez Gene: 11806 Mouse
Omim: 107680 Human
SwissProt: P02647 Human
SwissProt: Q00623 Mouse
Unigene: 93194 Human
Unigene: 26743 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
英文名称HDL
中文名称高密度脂蛋白抗体
别 名APOA1; APOA2; APOC1; Apolipoprotein A C I; Apolipoprotein A I; Apolipoprotein A II; High Density Lipoprotein.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 免疫学 内分泌病
抗体来源mouse
克隆类型monoclonal
交叉反应Rabbit产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位分泌型蛋白
性 状Liquid
浓 度1mg/1ml
免 疫 原human HDL from plasma
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
HDL is a cholesterol carrier protein that acts as scavenger of tissue cholesterol. It is important in cholesterol efflux from tissues, ａnd involved in the return of cholesterol from the periphery to the liver for removal as bile acids.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, ａnd it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, ａnd with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008].
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues ａnd by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subunit:
Interacts with APOA1BP ａnd CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain ａnd albumin. Interacts with NDRG1.
Subcellular Location:
Secreted.
Tissue Specificity:
Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver ａnd small intestine. The oxidized form at Met-110 ａnd Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype ａnd exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I ａnd increased levels are seen with increasing severity of disease.
Post-translational modifications:
Palmitoylated.
Met-110 ａnd Met-136 are oxidized to methionine sulfoxides.
Phosphorylation sites are present in the extracellular medium.
Similarity:
Belongs to the apolipoprotein A1/A4/E family.
SWISS:
P02647
Gene ID:
335
Database links:
Entrez Gene: 335 Human
Entrez Gene: 11806 Mouse
Omim: 107680 Human
SwissProt: P02647 Human
SwissProt: Q00623 Mouse
Unigene: 93194 Human
Unigene: 26743 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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- 2017/5/19mouse Anti-HDL antibody，高密度脂蛋白抗体
