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亨廷顿蛋白 (phospho Ser421) 多克隆抗体Huntingtin (phospho Ser421) Polyclonal Antibody

点击次数:135发布时间:2016/12/23 7:39:56

亨廷顿蛋白 (phospho Ser421) 多克隆抗体Huntingtin (phospho Ser421) Polyclonal Antibody

更新日期:2021/11/25 6:38:25

所 在 地:中国大陆

产品型号:ABP54728

简单介绍:Huntingtin is a disease gene linked to Huntington´s disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large,

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艾美捷科技有限公司,目前提供Abbkine高质量抗体:亨廷顿蛋白 (phospho Ser421) 多克隆抗体,性价比非常高。Abbkine致力于为全球生命科学研究和医疗发展提供*新的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品,包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案,从而为全球的科学家节省时间并提高研究效率。作为Abbkine的中国区域总代理,艾美捷科技有限公司凭借丰富的专业经验,将一如既往的为中国区域客户提供Abbkine优质的产品和技术服务。

Abbkine

【英文名称】:Huntingtin (phospho Ser421) Polyclonal Antibody

【中文名称】:亨廷顿蛋白 (phospho Ser421) 多克隆抗体

【产品类型】:一抗

【供应商】:Abbkine

【产品货号】:ABP54728

【背景资料】:Huntingtin is a disease gene linked to Huntington´s disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington´s disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5´ UTR that inhibits expression of the huntingtin gene product through translational repression.
蛋白别名为:HTT; HD; IT15; Huntingtin; Huntington disease protein; HD protein;基因ID为:3064;蛋白质ID:P42858

【产品规格】:30u/100ul/200ul

【应用类型】:IHC-p,ELISA
补充:*优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.

【免疫原】:合成多肽:human Huntingtin around the phosphorylation site of S421.

【来源宿主】:兔

【反应性】:人,小鼠,大鼠

【保存建议】:厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失,请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.
本产品为液体形式,溶解于PBS缓冲液中,含50%甘油,0.5%BSA和0.02%叠氮化钠.

【产品说明】:点击:亨廷顿蛋白 (phospho Ser421) 多克隆抗体查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-857垂询Abbkine中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看每日生物评论网站。

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现货一抗,植物Actin内参,线粒体内参抗体,性价比高内参抗体,β-Actin抗体,高质量,核内参PCNA抗体,内参抗体高质量,GAPDH抗体,β-Tubulin抗体,内参抗体高品质,植物内参Rubisco,艾美捷科技有限公司品线覆盖生物研究各个领域,主要包括:分子生物学(核酸蛋白研究工具、cDNA/RNA、转染试剂、植物组培/细胞培养、生化试剂及试剂盒),试剂药品(蛋白酶抑制剂、化合物、荧光染料/探针、动物血清)、抗体(一抗、二抗、封闭血清), 蛋白及试剂盒(细胞因子/重组蛋白、细胞凋亡/代谢/损伤、表观遗传、天然免疫)等。艾美捷为您寻找并提供*优的产品解决方案、*完备的物流服务、*及时的售后服务。如果您对上述产品线感兴趣,请致电免费服务热线400-6800-869到艾美捷垂询相关产品信息及完整实验解决方案。

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