艾美捷科技有限公司，目前提供Abbkine高质量抗体:活化STAT蛋白抑制因子4 多克隆抗体，性价比非常高。Abbkine致力于为全球生命科学研究和医疗发展提供*新的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为全球的科学家节省时间并提高研究效率。作为Abbkine的中国区域总代理，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abbkine优质的产品和技术服务。

【英文名称】：PIASy Polyclonal Antibody

【中文名称】：活化STAT蛋白抑制因子4 多克隆抗体

【产品类型】：一抗

【供应商】：Abbkine

【产品货号】：ABP55541

【背景资料】：The protein inhibitor of activated Stat (PIAS) proteins, which include PIAS1, PIAS3, PIASx, and PIASy, were originally characterized based on their interaction with the Stat family of transcription factors . PIAS1, PIAS3, and PIASx interact with and repress Stat1, Stat3, and Stat4, respectively . Deletion of PIAS1 leads to inhibition of interferon-inducible genes and increased protection against infection. The PIAS family contains a conserved RING domain that has been linked to a function as a small ubiquitin-related modifier (SUMO) ligase, coupling the SUMO conjugating enzyme Ubc9 with its substrate proteins . Numerous studies have now shown that PIAS family members can regulate the activity of transcription factors through distinct mechanisms, including NF-κB , c-Jun, p53 , Oct-4, and Smads . The activity of PIAS1 is regulated by both phosphorylation and arginine methylation. Inflammatory stimuli can induce IKK-mediated phosphorylation of PIAS1 at Ser90, which is required for its activity . In addition, PRMT1 induces arginine methylation of PIAS1 at Arg303 following interferon treatment and is associated with its repressive activity on Stat1. PIAS4, also known as PIASy, is a specific SUMO-E3 ligase for Ets-1 and represses Ets-1 dependent transcription . PIAS4 also alters the nuclear localization, reduces the transcriptional activity of C/EBPδ, and enhances cell proliferation and migration .
蛋白别名为：PIAS4; PIASG; E3 SUMO-protein ligase PIAS4; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma;基因ID为：51588；蛋白质ID:Q8N2W9

【产品规格】：30u/100ul/200ul

【应用类型】：WB，IHC-p，ELISA
补充：*优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.

【免疫原】：合成多肽：the C-terminal region of human PIASy. at AA rangle: 420-500

【来源宿主】：兔

【反应性】：人，小鼠

【保存建议】：厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.
本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%叠氮化钠.

【产品说明】：点击：活化STAT蛋白抑制因子4 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-857垂询Abbkine中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。

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