资料简介： 英文名称    phospho-CD151 (Ser30)    

中文名称    磷酸化CD151抗体    

别    名    CD151 antigen; CD151 molecule; GP27; Membrane glycoprotein SFA1; MER2; PETA3; Platelet endothelial tetraspan antigen 3; RAPH; SFA 1; SFA1; Tetraspanin24; TSPAN24; CD151_HUMAN; Platelet-endothelial tetraspan antigen 3; PETA-3; Tetraspanin-24; Tspan-24; CD151.    

磷酸化CD151抗体    

产品类型    磷酸化抗体     

研究域    信号转导  细胞粘附分子  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    28kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human CD151 around the phosphorylation site of Ser30    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 磷酸化CD151抗体    

产品介绍    background:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth ａnd motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins ａnd other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion ａnd may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion ａnd metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].

Function:
Essential for the proper assembly of the glomerular ａnd tubular basement membranes in kidney.

Subunit:
Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 ａnd alpha6beta4, with CD9 ａnd CD181.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in a variety of tissues including vascular endothelium ａnd epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.

DISEASE:
Nephropathy with pretibial epidermolysis bullosa ａnd deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, ａnd beta-thalassemia minor. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the tetraspanin (TM4SF) family.