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丙型肝炎病毒NS5B抗体
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详细内容
产品名称 | 丙型肝炎病毒NS5B抗体 |
英文名称 | Hepatitis C virus NS5B |
货号 | GOY-01K4598 |
别 名;HCV NS5B; Hepatitis C virus NS5B; Non structural protein 5B; p68; RNA dependent RNA polymerase; RNA directed RNA polymerase; Hepatitis C virus; Hepatitis C virus subtype 1a; Hepatitis C virus subtype 2a; Hepatitis C virus subtype 1b; Hepatitis C virus subtype 2c; Hepatitis C virus subtype 3a; Hepatitis C virus genotype 2; Hepatitis C virus subtype 6a. 研究域;微生物学 细菌及病毒 抗体来源;Rabbit 克隆类型;Polyclonal 产品应用;ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 理论分子量;11kDa 性 状;Liquid 浓 度;1mg/ml 免 疫 原;KLH conjugated synthetic peptide derived from Hepatitis C virus NS5B.: 21-102/102 亚 型;IgG 纯化方法;affinity purified by Protein A 缓 冲 液;0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件;Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cylasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis). |
一抗结构:
二抗的原理及特点:
嘌呤元素结合蛋白G封闭多肽 | 叉头蛋白D3抗体 |
Kelch样蛋白33封闭多肽 | CD70抗体 |
His 结构域内含酪氨酸磷酸酶蛋白封闭多肽 | NK细胞受体2D抗体 |
锌指蛋白98封闭多肽 | 锌指蛋白502抗体 |
IMPG1蛋白封闭多肽 | 突变的黑色素瘤相关抗原1抗体 |
锌指蛋白BED封闭多肽 | 热休克转录因子2抗体 |
KBTBD2蛋白封闭多肽 | RAS相关抑细胞生长蛋白1抗体 |
锌指蛋白800封闭多肽 | 血管活性肠肽受体-1抗体 |
HRASLS5蛋白封闭多肽 | 多核苷酸磷酸化酶蛋白抗体 |
锌指蛋白780B封闭多肽 | B淋巴细胞酪氨酸激酶抗体 |
I类组织相容性H-2抗原D-Dalpha链封闭多肽 | 环指蛋白47抗体 |
锌指蛋白3封闭多肽 | 钠碘转运体蛋白8抗体 |
PHD指蛋白21A封闭多肽 | 丙型肝炎病毒NS5B抗体纺锤体点构成蛋白25抗体 |
西酮/2-(甲基氨基)-1-苯基-1-丙酮-BSA偶联物 | 特异性囊肿病液体蛋白15 |
Erbin蛋白封闭多肽 | 有丝分裂激酶B抗体 |