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丙型肝炎病毒1b抗体
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详细内容
产品名称 | 丙型肝炎病毒1b抗体 |
英文名称 | Hepatitis C Virus 1b Core protein p19 |
货号 | GOY-0189 |
别 名;Core protein p19; HCV core antigen; HCV core protein; Hepatitis C Virus core protein; polyprotein [Hepatitis C virus subtype 1b]. 研究域;细胞生物 细菌及病毒 抗体来源;Rabbit 克隆类型;Polyclonal 产品应用;ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 理论分子量;7.6/21kDa 性 状;Liquid 浓 度;1mg/ml 免 疫 原;KLH conjugated synthetic peptide derived from Hepatitis C Virus 1b Core protein p19: 71-170/201 亚 型;IgG 纯化方法;affinity purified by Protein A 缓 冲 液;0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件;Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cylasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis). |
一抗结构:
二抗的原理及特点:
内质网Aβ相关结合蛋白封闭多肽 | IQCE蛋白抗体 |
Kelch样蛋白20封闭多肽 | Rad51抗体 |
HHLA2蛋白封闭多肽 | 细胞色素c氧化酶IV亚型1抗体 |
锌指蛋白BED3封闭多肽 | 腺苷受体A3抗体 |
IL-2诱导型T细胞激酶封闭多肽 | 环指蛋白1抗体 |
锌指蛋白RIZ1封闭多肽 | 周期蛋白结合蛋白抗体 |
KBP蛋白封闭多肽 | RAS相关蛋白Rab5B抗体 |
整合素相互作用蛋白Kindlin封闭多肽 | 血管假性血友病因子/血管性血友病因子抗体 |
HORMAD1蛋白封闭多肽 | CP2相关转录抑制因子1抗体 |
锌指蛋白789封闭多肽 | B淋巴细胞成熟因子(CD269)抗体 |
I型胶原封闭多肽 | 有丝分裂驱动蛋白样2B抗体 |
锌指蛋白408封闭多肽 | FAM58A蛋白抗体 |
锌指蛋白780B封闭多肽 | 丙型肝炎病毒1b抗体WBP2单克隆抗体 |
磷酸化间变型淋巴瘤激酶封闭多肽 | RNA结合蛋白34抗体 |
磷酸化组蛋白去乙酰化酶1封闭多肽 | 原钙粘蛋白7抗体 |