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磷酸化血小板源性生长因子受体-B抗体
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详细内容
产品名称 | 磷酸化血小板源性生长因子受体-B抗体 |
英文名称 | Phospho-PDGF Receptor beta (Tyr740) |
货号 | GOY-01K2720 |
别 名;PDGFRB(phospho Y740); PDGF Receptor beta (phospho Y740); PDGF Receptor beta (phospho Tyr740); Beta platelet derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD 140B; CD140 antigen-like family member B; CD140B; CD140B; CD140b antigen; JT; OTTHUMP00000160528; PDGF R beta; PDGF-R-beta; PDGFR 1; PDGFR; PDGFR beta; PDGFR1; PDGFRB; PGFRB_HUMAN; Platelet derived growth factor receptor 1; Platelet derived growth factor receptor beta; Platelet derived growth factor receptor beta; polypeptide. 产品类型;磷酸化抗体 研究域;肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 细胞膜受体 抗体来源;Rabbit 克隆类型;Polyclonal 交叉反应;(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) 产品应用;WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 理论分子量;190kDa 细胞定位;细胞浆 细胞膜 性 状;Liquid 浓 度;1mg/ml 免 疫 原;KLH conjugated Synthesised phosphopeptide derived from human PDGF Receptor beta around the phosphorylation site of Tyr740: GG(p-Y)MD 亚 型;IgG 纯化方法;affinity purified by Protein A 保存条件;Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. |
一抗结构:
二抗的原理及特点:
一抗和二抗的区别:
蛋白磷酸酶γ1封闭多肽 | 胶质瘤发病相关蛋白1抗体 |
端粒体复制结合因子1封闭多肽 | 细胞色素C氧化酶17抗体 |
蛋白酶体PSMβ3封闭多肽 | 磷酸化粘着斑激酶抗体 |
妊娠区带蛋白PZP封闭多肽 | 纤维连接蛋白抗体 |
蛋白激酶锚定蛋白13封闭多肽 | ZDHHC19蛋白抗体 |
人纤维蛋白原(进口) | 锌指蛋白ZBTB12抗体 |
蛋白酶体PSMα8封闭多肽 | 骨形态发生蛋白15抗体 |
磷酸化血管生成素受体2封闭多肽 | 细胞内流钾通道蛋白Kir4.1抗体 |
蛋白酶样凋亡调节蛋白CASH封闭多肽 | 附睾分泌蛋白4抗体 |
去整合素样金属蛋白酶2封闭多肽 | FBXW10蛋白抗体 |
丙酮酸脱氢酶E2封闭多肽 | 紫外切除修复蛋白RAD23A抗体 |
羟基类固醇脱氢酶11β1封闭多肽 | 细胞角膜蛋白多糖抗体 |
分泌载体膜蛋白2封闭多肽 | 磷酸化血小板源性生长因子受体-B抗体腺嘌呤磷酸核糖转移酶抗体 |
重组单体樱桃红荧光蛋白 | 磷酸化肿瘤蛋白P73抗体 |
磷酸化核糖体S6蛋白激酶封闭多肽 | FITC标记小鼠抗人CD19单克隆抗体 |