Wortmannin 是一种多靶点抑制剂，能够抑制 PI3K 和 MLCK 的活性，IC₅₀ 值分别为 3 nM 和 170 nM。
Betamethasone产品描述：Betamethasone is a glucocorticoid steroid with anti-inflammatory ａnd immunosuppressive properties. Target: Glucocorticoid Receptor Betamethasone is a potent glucocorticoid steroid with anti-inflammatory ａnd immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. The median (range) IC50 value for betamethasone butyrate propionate evaluated in the streptococcal pyrogenic enterotoxin A-stimulated peripheral-blood mononuclear cells was 291.6 (0.001-1171.5) ng/ml, which was significantly higher than the value 0.072 (0.01-222.5) ng/ml found in concanavalin A-stimulated peripheral-blood mononuclear cells (P=0.0245) [1]. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg) [2]. Intra-ar


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产品链接：www.medchemexpress.cn/betamethasone.html


Purity:98%
MWt:428.4319
Formula:C23H24O8
SMILES:O=C1C([C@@](CC2)([H])[C@@]3(C)C2=O)=C([C@H](OC(C)=O)C3)[C@]4(C)C5=C1OC=C5C(O[C@@H]4COC)=O
Pathway:Cell Cycle/DNA Damage; PI3K/Akt/mTOR;
Mechanisms:ATM/ATR; DNA-PK; PI3K;
Research Area:Cancer
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