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Piperlongumine_荜茇酰胺
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Piperlongumine
CAS No. : 20069-09-4
MCE 站:Piperlongumine
产品活性:Piperlongumine 是从荜茇中得到的生物碱,具有抗炎、抗菌、抗血管生成、抗氧化、抗肿瘤和抗糖尿病等活性。在肿瘤细胞中,Piperlongumine 能够诱导 ROS 和凋亡。Piperlongumine 具有抗心肌纤维化的作用,通过抑制 ERK1/2 信号通路抑制肌成纤维细胞的转化。
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Autophagy | Apoptosis | Anti-infection
作用靶点:ERK | Reactive Oxygen Species | Autophagy | Apoptosis | Bacterial | Ferroptosis
In Vitro: Piplartine (5, 10, and 15 μM) significantly decreases cell proliferation of 786-O, SKBR3, Panc1, A549, and L3.6pL cancer cells after treatment for 24 and 48 hours, induces apoptosis and ROS in these cell lines at 5 and 10 μM after 3 or 9 h of treatment.
Piplartine (5 or 10 μM) induces cleaved PARP and downregulates Sp1, Sp3, Sp4, and Sp-regulated genes.
Piplartine (20 μM) decreases the viability of cardiac fibroblasts (CFs). Piplartine (0-10 μM) suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.
In Vivo: Piperlongumine (30 mg/kg/day, i.p. for 3 weeks) exhibits potent anti-tumor effect in athymic nude mice bearing L3.6pL cells without body weight loss.
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热门标签:Piplartine