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Zinc Protoporphyrin
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Zinc Protoporphyrin
CAS No. : 15442-64-5
MCE 站:Zinc Protoporphyrin
产品活性:Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的,竞争性的血红素加氧酶-1 (HO-1) 抑制剂,显着减弱间苯三酚 (PG) 对 H2O2 的保护作用。Zinc Protoporphyrin 可用作个体孕妇和儿童缺铁的筛查标志物,也用于评估人群铁状态与血红蛋白浓度的组合。Zinc Protoporphyrin 具有抗癌活性。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis
作用靶点:Reactive Oxygen Species | Endogenous Metabolite | Apoptosis
In Vitro: Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.
In Vivo: Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.
相关产品:Human Endogenous Metabolite Compound Library | Apoptosis Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | NF-κB Signaling Compound Library | Orally Active Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Ferroptosis Compound Library | Anti-Cancer Compound Library | Metabolism/Protease Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Pyroptosis Compound Library | Rapamycin | MG-132 | 3-Methyladenine | LY294002 | Actinomycin D | Mitomycin C | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | SP600125 | Sorafenib | Angiotensin II human | MK-2206 dihydrochloride | 5-Fluorouracil | H2DCFDA | Trametinib | Bortezomib | Tamoxifen | Gemcitabine | Pexidartinib | Acetylcysteine | Decitabine | BAY 11-7082 | 2-Deoxy-D-glucose | Temozolomide | Docetaxel | Dasatinib | Verteporfin
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热门标签:Zn(II)-protoporphyrin IX