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Aristolochic acid A

CAS No. : 313-67-7

MCE 站：Aristolochic acid A

产品活性：Aristolochic acid A (Aristolochic acid I; TR 1736) 是植物提取物 Aristolochic acids 的主要成分，其存在于 Aristolochia 和 Asarum 草本植物中。Aristolochic acid A 显着降低激活蛋白1 (AP-1) 和 NF-κB 活性。Aristolochic acid A 降低人细胞中膀胱癌相关 BLCAP 基因表达。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: Aristolochic acid A (150, 200 μM, 24?hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2.
Aristolochic acid A (100, 200 μM, 24?hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376).
Aristolochic acid A (100, 200 μM, 24?hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells.

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