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Guanidinosuccinic acid

CAS No. : 6133-30-8

MCE 站：Guanidinosuccinic acid

产品活性：Guanidinosuccinic acid 是从血清和尿液中分离出的含氮代谢物，在尿毒症患者的尿液和血清中升高。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vivo: Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD₅₀ (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD₅₀ of 579 (445-756) mg/kg. The CD₅₀ of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.

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