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Semaglutide

CAS No. : 910463-68-2

MCE 站：Semaglutide

产品活性：Semaglutide 是人胰高血糖素样肽-1 的一个长效类似物， 是人胰高血糖素样肽-1 (GLP-1) 受体的激动剂。Semaglutide 有潜力用于 2 型糖尿病的研究。

研究领域：GPCR/G Protein

作用靶点：Glucagon Receptor

In Vitro: Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib⁸, Arg³⁴) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1.

In Vivo: The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to liraglutide in most parameters. Semaglutide lowers blood glucose by stimulating the release of insulin and also lowers body weight.

相关产品：FDA-Approved Drug Library Plus  |  Drug Repurposing Compound Library Plus  |  Bioactive Compound Library Plus  |  Exendin-4  |  Liraglutide  |  Glucagon  |  Adomeglivant  |  Avexitide  |  Semaglutide TFA  |  GLP-1(7-36) Acetate  |  MK 0893  |  GLP-1(7-37)  |  Tirzepatide hydrochloride  |  Lixisenatide  |  GLP-1 receptor agonist 1  |  GRA Ex-25  |  BETP  |  LGD-6972  |  Taspoglutide  |  GLP-1 receptor agonist 2  |  GLP-2(1-33)(human)  |  Glucagon-like peptide 1 (1-37), human TFA  |  GLP-1 moiety from Dulaglutide  |  NNC-0640  |  PF-06291874  |  Cotadutide acetate  |  Glucagon receptor antagonists-3  |  Human growth hormone-releasing factor  |  Exendin-3/4 (59-86)  |  FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  Glucagon receptor antagonists-1

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