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Cyclovirobuxine D

CAS No. : 860-79-7

MCE 站：Cyclovirobuxine D

产品活性：Cyclovirobuxine D (CVB-D) 是中药黄杨 Buxus microphylla 的主要活性成分。Cyclovirobuxine D 诱导自噬并减弱 Akt 和 mTOR 的磷酸化。Cyclovirobuxine D 通过抑制细胞周期进程和诱导线粒体介导的细胞凋亡 apoptosis 抑制癌细胞的增殖。Cyclovirobuxine D 治疗心肌梗死引起的心力衰竭，具有治疗心力衰竭的潜力。

研究领域：Apoptosis  |  Autophagy  |  PI3K/Akt/mTOR

作用靶点：Apoptosis  |  Autophagy  |  mTOR  |  Akt

In Vitro: Cyclovirobuxine D (0-240 ?M ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 ?M.
Cyclovirobuxine D (0-120 ?M; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner.
Cyclovirobuxine D (0-120 ?M; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis.Cyclovirobuxine D (0-120 ?M; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells.

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