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Glabridin

CAS No. : 59870-68-7

MCE 站：Glabridin

产品活性：Glabridin 是从 Glycyrrhiza glabra 中分到的异黄烷类，能够结合并激活 PPARγ，EC₅₀ 值为 6115 nM。Glabridin 具有抗氧化、抗菌、抗肾炎、抗糖尿病、抗肿瘤、抗炎、抗骨质疏松、保护心血管、保护神经、清除自由基等作用。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Anti-infection

作用靶点：PPAR  |  Reactive Oxygen Species  |  Bacterial

In Vitro: Glabridin binds to and activates PPARγ, with an EC₅₀ of 6115 nM.
Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h.
Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines.
Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, ?8, and ?9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells.

In Vivo: Glabridin (50 mg/kg, p.o. once daily) shows potent anti-inflammatory activity, ameliorates the inflammatory alterations induced by Dextran sodium sulphate (DSS) in rats.

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