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Stachydrine hydrochloride

CAS No. : 4136-37-2

MCE 站：Stachydrine hydrochloride

产品活性：Stachydrine hydrochloride 是 Herba Leonuri 的主要活性成分，可用于治疗心血管疾病。Stachydrine hydrochloride 可以抑制 NF-κB 信号通路。具有抗心肌肥大活性 。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: Intervention of Stachydrine significantly suppresses the level of p-IκB (ser32) protein in the cytosol and NF-κB (p65) protein in the nucleus (P<0.05).
Treatment with Stachydrine hydrochloride (50 ?M, 200 ?M, 500 ?M and 1000 ?M) noticeably inhibited MCF-7 and T47D cell proliferation in dose- and time-dependent manner.
High concentrations (500 ?M and 1000 ?M) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle, suggesting that Stachydrine hydrochloride could cause cell cycle arrest.

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