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Selgantolimod

CAS No. : 2004677-13-6

MCE 站：Selgantolimod

产品活性：Selgantolimod (GS-9688) 是一种口服活性，有效和选择性的 Toll 样受体 8 (TLR8) 激动剂，用于治疗乙型肝炎病毒 (HBV) 和 HIV 感染。

研究领域：Immunology/Inflammation  |  Anti-infection

作用靶点：Toll-like Receptor (TLR)  |  HBV

In Vitro: Selgantolimod induces the cellular immune mediators interleukin (IL)-12 and IL-8, as well as the antiviral cytokines tumor necrosis factor-α and interferon-γ (IFNγ) in vitro in human perpheral blood mononuclear cells.
Selgantolimod activates natural killer (NK) and mucosal associated invariant T cells, stimulates cluster of differentiation (CD)-8⁺ T-cell proliferation, and increas IFNγ production, while lowering programmed cell death protein 1 expression by HBV-specific CD8⁺-T cells in vitro in peripheral blood mononuclear cells.
Selgantolimod-induced cytokines reduce HBV DNA, RNA, and antigen levels in HBV-infected primary human hepatocytes.

In Vivo: Once-weekly dosing of oral Selgantolimod induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys, and leads to functional cure in the woodchuck model of chronic HBV.

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