MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

Centanafadine hydrochloride

CAS No. : 923981-14-0

MCE 站：Centanafadine hydrochloride

产品活性：Centanafadine (hydrochloride) 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运的双抑制剂，还能抑制5-羟色胺 (serotonin) 转运体，其对人 NE，DA 和5-羟色胺转运体的IC₅₀ 值分别为6 nM，38 nM 和 83 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor  |  Dopamine Transporter  |  Serotonin Transporter

In Vitro: Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters with IC₅₀ values of 6 and 38 nM, respectively, for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT with an IC₅₀ value of 83 nM .

In Vivo: In microdialysis studies, Centanafadine markedly increases NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increases DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrate that Centanafadine dose-dependently decreases immobility in the mouse tail suspension test of depression to 13% of control levels, and do not stimulate locomotor activity in adult rats in the optimal dose range. Centanafadine dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternally) as neonates; a well-established animal model for attention-deficit hyperactivity disorder (ADHD).

相关产品：Endocrinology Compound Library  |  Drug Repurposing Compound Library  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Clinical Compound Library  |  Neurotransmitter Receptor Compound Library  |  Clinical Compound Library Plus  |  Drug Repurposing Compound Library Plus  |  Bioactive Compound Library Plus  |  Isoprenaline hydrochloride  |  ICI 118,551 hydrochloride  |  Norepinephrine bitartrate monohydrate  |  Propranolol hydrochloride  |  (R)-(-)-Phenylephrine hydrochloride  |  Fluoxetine hydrochloride  |  Deschloroclozapine  |  L-Epinephrine  |  Yohimbine Hydrochloride  |  Pimozide  |  Paroxetine hydrochloride  |  Trifluoperazine dihydrochloride  |  Atenolol  |  Carvedilol  |  Mirabegron  |  Prazosin hydrochloride  |  Fluvoxamine maleate  |  Desipramine hydrochloride  |  Imipramine hydrochloride  |  Ivabradine hydrochloride  |  Olanzapine  |  Sertindole  |  Vanoxerine dihydrochloride  |  Fipexide  |  Pindolol  |  Sertraline hydrochloride  |  Dexmedetomidine hydrochloride  |  Phentolamine mesylate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。