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GS-441524

CAS No. : 1191237-69-0

MCE 站：GS-441524

产品活性：GS-441524 对猫传染性腹膜炎病毒 (FIPV) 有较强的抑制作用，对应的 EC₅₀ 值为 0.78 μM。

研究领域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：DNA/RNA Synthesis  |  Influenza Virus

In Vitro: The cells appear and grow normally at all concentrations of GS-441524 and fail to uptake the fluorescent dye CellTox Green at 24 h. The cytotoxic concentration-50% (CC50) is therefore>100 μM. The effective concentration-50% (EC₅₀) of GS-441524 is calculated to be 0.78 μM.

In Vivo: All 10 treated cats have a rapid response to treatment and lymphocyte levels and rectal temperatures return to pre-infection levels and levels of the two asymptomatic cats. Two of the 10 treated cats, 16-116 (Group A) and 16-127 (Group B), have recurrences disease at four and six weeks post treatment. These two cats are treated a second time for two weeks and their response is identical to that of primary treatment. All ten of the once or twice treated cats have remained normal to date (more than eight months post infection). Injections cause a transient "stinging" reaction in some cats within 10 s of compound administration. Localized and transient pain is evidenced by unusual posturing, licking at the injection site and/or vocalizations that last for approximately 30-60 s after injection. Injection reactions are more pronounced in some animals relative to others and reactions are inconsistent from one injection to the next and decreas over time.

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