MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

ONO-8590580

CAS No. : 1802661-73-9

MCE 站：ONO-8590580

产品活性：ONO-8590580 是 GABA_A α5 的负变构调节剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vivo: The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice.

相关产品：Neuronal Signaling Compound Library  |  Neurotransmitter Receptor Compound Library  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  (+)-Bicuculline  |  Picrotoxin  |  Aminooxyacetic acid hemihydrochloride  |  Fluxametamide  |  Gabazine  |  Riluzole  |  Vigabatrin  |  (R)-Baclofen  |  γ-Aminobutyric acid  |  Cenobamate  |  Basmisanil  |  CGP52432  |  Etifoxine  |  Isoguvacine hydrochloride  |  Dihydroergotoxine mesylate  |  Flumazenil  |  Tiagabine hydrochloride  |  Topiramate  |  Etomidate  |  SKF89976A hydrochloride  |  Ginkgolide A  |  Guvacine hydrochloride  |  L-655708  |  Zuranolone  |  Ginsenoside Rc  |  Methionine  |  (-)-Securinine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。