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C-176

CAS No. : 314054-00-7

MCE 站：C-176

产品活性：C-176 是干扰素基因刺激受体 (STING) 的强效共价抑制剂。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vitro: C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.

In Vivo: C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1^?/? mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1^?/? mice.

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