MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

ANI-7

CAS No. : 931417-26-4

MCE 站：ANI-7

产品活性：ANI-7 是一种 AhR 途径的激活剂。ANI-7 抑制多种癌细胞的生长，并有选择地抑制 MCF-7 乳腺癌细胞的生长，GI₅₀ 为 0.56 μM。ANI-7 通过激活 AhR 途径诱导 CYP1 代谢单加氧酶，并在敏感的乳腺癌细胞系中诱导 DNA 损伤，检查点激酶 (Chk2) 激活，S 期细胞周期停滞和细胞死亡。

研究领域：Immunology/Inflammation  |  Cell Cycle/DNA Damage

作用靶点：Aryl Hydrocarbon Receptor  |  Checkpoint Kinase (Chk)

In Vitro: ANI-7 (2.5 μM; 24 hours; MCF10A and MDA-MB-468 cells) treatment induces significant S-phase and G2 + M-phase cell cycle arrest within 24 hours of treatment in MDA-MB-468 cells, and negligible effect in normal breast MCF10A cells.
ANI-7 (2 μM; 12-24 hours; MDA-MB-468 cells) treatment results in a significant increase in the content and phosphorylation of CHK2, and induces a significant increase in H2AX? in MDA-MB-468 cells, indicative of DNA double-strand damage.
Inhibition of the AhR pathway ameliorates the effects of ANI-7. ANI-7 activates XRE activity and expression of the AhR and CYP1 members.
Comparisons of the GI₅₀ values show that ANI-7 produces a GI₅₀ value of 0.38 μM in MCF-7 cells, whereas values of 3.0-42 μM are observed in cell lines from lung, colon, ovary, neuronal, glial, prostate, and pancreas. The only other tumor type that shows appreciable growth inhibition by ANI-7 is the A431 vulva cell line (GI₅₀ of 0.51μM).
ANI-7 potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells (GI₅₀ range of 0.16-0.38 μM), moderately inhibits the growth of BT20 and BT474 cells (GI50 range of 1-2 μM), and essentially fails to inhibit the growth of MDA-MB-231 and MCF10A cells (GI₅₀ range of 17-26 μM). Moreover, ANI-7 maintained its ability to inhibit the growth of drug-resistant cells (MCF-7/VP16: GI₅₀ of 0.21 μM).

相关产品：Anti-Aging Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  PD98059  |  Pifithrin-α hydrobromide  |  Prexasertib  |  CH-223191  |  AZD-7762  |  FICZ  |  StemRegenin 1  |  Rabusertib  |  L-Kynurenine  |  CCT245737  |  SCH900776  |  Tapinarof  |  ITE  |  CHIR-124  |  2OH-BNPP1  |  BML-277  |  CCT241533 hydrochloride  |  Diosmin  |  PF 477736  |  CCT244747  |  GNF351  |  Indole-3-carbinol  |  GDC-0575  |  AHR antagonist 1  |  PDM2  |  PD 407824  |  Skatole  |  Cardamonin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。