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AZD7507

CAS No. : 1041852-85-0

MCE 站：AZD7507

产品活性：AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂，具有抗肿瘤活性。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Fms

In Vitro: AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC₅₀, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC₅₀s of >30 and 26 μM.

In Vivo: AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC₅₀ is >20 μM. AZD7507 significantly decreases the number of CD68⁺ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.

相关产品：Orally Active Compound Library  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Bioactive Compound Library Plus  |  Pexidartinib  |  BLZ945  |  PLX5622  |  GW2580  |  Linifanib  |  Edicotinib  |  PRN1371  |  Pazopanib Hydrochloride  |  Ki20227  |  OSI-930  |  c-Fms-IN-1  |  DCC-3014  |  c-Fms-IN-2  |  c-Fms-IN-3  |  CSF1R-IN-2  |  GENZ-882706(Raceme)  |  JTE-952  |  PLX647  |  c-Fms-IN-10  |  c-Fms-IN-12  |  c-Fms-IN-8  |  c-Fms-IN-9  |  c-Fms-IN-6  |  c-Fms-IN-7  |  cFMS Receptor Inhibitor II  |  CSF1R-IN-1

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