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Ppc-1

CAS No. : 1245818-17-0

MCE 站：Ppc-1

产品活性：Ppc-1 是一种线粒体解偶联剂，可增加线粒体耗氧量，但不影响 ATP 的产生。Ppc-1 是一种细胞渗透性白介素 2 (IL-2) 抑制剂。Ppc-1 抑制革兰氏阴性牙周病原体 Porphyromonas gingivalis 的活性。Ppc-1 具有抗肥胖，抗菌和消炎的作用。

研究领域：Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  Anti-infection

作用靶点：Mitochondrial Metabolism  |  Interleukin Related  |  Bacterial

In Vitro: Ppc-1 treatment (0-10 μM; 24 hours; Jurkat cells) significant inhibits IL-2 production in Jurkat cells with an IC₅₀ of 4 μM.
Ppc-1 (compound 6) has antiproliferative activities in K562 human leukemia, Hela cervical carcinoma, and 3T3-L1 mouse embryonic fibroblast cells. Ppc-1 shows about 50% inhibition at 15 μM in all cell lines. Ppc-1 inhibits the growth of K562 cells with an EC₅₀ of 13 μM.Using the U937-3xκB-LUC human monocytic cell line, Ppc-1 dose-dependently inhibits the lipopolysaccharide-induced NF-κB activation.

In Vivo: Ppc-1 (0-10 mg /kg; Intraperitoneal injection; once a week; for 8 weeks; female ICR mice) treatment suppresses weight gain with no abnormal effects on liver or kidney tissues, and no evidence of tumor formation.
Serum fatty acid levels are significantly elevated in mice treated with Ppc-1, while body fat content remained low. After a single administration, Ppc-1 distributes into various tissues of individual animals at low levels. Ppc-1 stimulates adipocytes in culture to release fatty acids, which might explain the elevated serum fatty acids in Ppc-1-treated mice.

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