MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

LY3020371 hydrochloride

CAS No. : 1377615-44-5

MCE 站：LY3020371 hydrochloride

产品活性：LY3020371 hydrochloride 是一种有效的选择性代谢型谷氨酸 2/3 受体 (mGlu2/3) 拮抗剂，K_i 值分别为 5.3 nM 和 2.5 nM。LY3020371 hydrochloride 有效阻断 cAMP 形成，IC₅₀ 值为 16.2 nM。LY3020371 hydrochloride 在体内具有抗抑郁样特性。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mGluR

In Vitro: LY3020371 hydrochloride (LY3020371.HCl) displaces binding of the mGlu2/3 agonist ligand [³H]-459477 with high affinity (hmGlu2 K_i=5.26 nM; hmGlu3 K_i=2.50 nM).
LY3020371 hydrochloride (LY3020371.HCl) (0.1 nM-100 μM; 1 hours) potently blocks mGlu2/3 agonist (DCG-IV)-inhibited, forskolin-stimulated cAMP formation (IC₅₀=16.2 nM), an effect that was similarly observed in hmGlu3-expressing cells ( IC₅₀=6.21 nM).
LY3020371 hydrochloride (LY3020371.HCl) blocks agonist-suppressed spontaneous Ca²⁺ oscillations (IC₅₀=34 nM) and in an intact hippocampal slice preparation (IC₅₀=46 nM).

In Vivo: LY3020371 hydrochloride (LY3020371.HCl) (Intravenous injection; 3-15 mg/kg) in rats leads to cerebrospinal fluid drug levels that are expected to effectively block mGlu2/3receptors.
LY3020371 hydrochloride (LY3020371) (intraperitoneal injection; 3 mg/kg, 10?mg/kg; 2 hours) has clear wake promoting effects, resulting in a large reduction in NREM sleep in the Wistar rats during the light phase.

相关产品：L-Glutamine  |  Eglumegad  |  LY341495  |  MPEP Hydrochloride  |  DHPG  |  trans-ACPD  |  (S)-MCPG  |  JNJ16259685  |  Lu AF21934  |  Xanthurenic acid  |  FITM  |  ADX88178  |  CTEP  |  Mavoglurant  |  Dipraglurant  |  VU0364770  |  Basimglurant  |  Foliglurax monohydrochloride  |  JNJ-40411813  |  JNJ-46778212  |  L-APB  |  MTEP hydrochloride  |  VU0650786  |  LY2794193  |  LY404039  |  O-Phospho-L-serine  |  CPPHA  |  E4CPG  |  JNJ-42153605

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。