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DCZ0415

CAS No. : 2242470-43-3

MCE 站：DCZ0415

产品活性：DCZ0415 是一种有效的 TRIP13 抑制剂，可损害非同源末端连接修复并抑制 NF-κB 活性。DCZ0415 在体外，体内以及在耐药性骨髓瘤患者衍生的原代细胞中诱导抗骨髓瘤活性。

研究领域：NF-κB  |  Apoptosis

作用靶点：NF-κB  |  Apoptosis

In Vitro: DCZ0415 (10, 20 μM; 72 hours) shows a significant decrease in colony formation, indicating it inhibits cell proliferation.
DCZ0415 (1.25-40 μM; 72 hours) induces a significant dose-dependent decrease of viability inMM cells.
DCZ0415 (10, 20 μM; 24-72 hours) shows a dose-dependent relationship between DCZ0415 treatment and apoptotic cell death.
DCZ0415 (10, 20 μM; 24 hours) induces a significant accumulation in G0/G1 MM cells.
DCZ0415 (10 μM; 48 hours) decreases the protein levels of phosphorylated (p)-iκBα and phosphorylated (p)-NF-κB in MM cells.
DCZ0415 has IC₅₀s of 1.0–10 μM in CalcuSyn in MM cell lines.
DCZ0415 exerts cytotoxic effects by inhibiting DNA 288 synthesis in MM cells.

In Vivo: DCZ0415 (ip; 50 mg/kg/day for 14 days) significantly reduces the growth of MM cells-induced tumors in immune-deficient mice.

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