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CB-103

CAS No. : 218457-67-1

MCE 站：CB-103

产品活性：CB-103 是一种一线的、有口服活性的 notch 信号通路抑制剂，有抗肿瘤活性，详细信息请参考文献US9296682B2。

研究领域：Neuronal Signaling  |  Stem Cell/Wnt

作用靶点：Notch

In Vitro: CB-103 acts as a Pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex.
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines.
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.

In Vivo: CB-103 inhibits NOTCH dependent cellular processes in mice.
CB-103 blocks in vivo growth of PDX models of T-ALL.
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer.
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors.

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