MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

TFEB activator 1

CAS No. : 39777-61-2

MCE 站：TFEB activator 1

产品活性：TFEB activator 1 是一种口服有效的，不依赖 mTOR 的 TFEB 激活剂。TFEB activator 1 显着促进 Flag-TFEB 的核易位，EC₅₀ 为 2167 nM。TFEB activator 1 在不抑制 mTOR 通路的情况下增强自噬 (autophagy)。TFEB activator 1 有潜力用于神经退行性疾病的研究。

研究领域：Autophagy

作用靶点：Autophagy

In Vitro: TFEB activator 1 (Compound C1) activates TFEB (transcription factor EB) by directly binding to TFEB and promotes its entry into the nucleus, without affecting TFEB phosphorylation or inhibiting the activities of MTOR and MAPK1/ERK2-MAPK3/ERK1.
TFEB activator 1 (1 μM; for 12 h) significantly increases the levels of LC3B-II, the lipidated and phagophore- or autophagosome-associated form of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 β) in N2a cells.
TFEB activator 1 (0.2-1 μM) dose-dependently increases the levels of LC3-II and SQSTM1/p62 (sequestosome 1) in N2a cells.

In Vivo: The medium lethal dose (LD₅₀) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats) .
Short-term oral administration of TFEB activator 1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain.
Chronic administration of TFEB activator 1 (10 mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains.

相关产品：Rapamycin  |  MG-132  |  Cycloheximide  |  3-Methyladenine  |  LY294002  |  Olaparib  |  Actinomycin D  |  Cisplatin  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Chloroquine phosphate  |  Venetoclax  |  Paclitaxel  |  Metformin hydrochloride  |  (+)-JQ-1  |  Resatorvid  |  SB 203580  |  CHIR-99021  |  SP600125  |  Sorafenib  |  Enzalutamide  |  U0126-EtOH  |  MK-2206 dihydrochloride  |  Trametinib  |  Forskolin  |  Tamoxifen  |  Bortezomib  |  PD98059  |  Gemcitabine  |  Oxaliplatin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。