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TPh A

CAS No. : 21306-65-0

MCE 站：TPh A

产品活性：TPh A (Triphenyl Compound A) 是核蛋白 pirin 的有效抑制剂，其 K_i 值为0.6 uM。TPh A 破坏 Bcl3-pirin 复合物的形成。TPh A 可作为相关的小分子工具调控细胞内的 Pirin。

研究领域：Others

作用靶点：Others

In Vitro: The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily.
TPh A (20 μM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection).
TPh A (0-100 μM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC₅₀ values >50 μM, and exhibits IC₅₀ values of 27 μM, 20 μM and 26 μM for PC3 HL60 and HT29 cells, respectively.
TPhA (0-50 μM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner.

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