MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

Brilacidin tetrahydrochloride

CAS No. : 1224095-99-1

MCE 站：Brilacidin tetrahydrochloride

产品活性：Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) 对多种革兰氏阴性和革兰氏阳性病原体的耐药菌株和敏感菌株具有有效的杀菌 (anti-bactericidal) 活性。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: Both Staphylococcus aureus (SA) and Staphylococcus epidermidis (SE) have the lowest minimum inhibitory concentrations among the bacterial groups. The MIC₉₀s to Brilacidin for Streptococcus pneumonia (SP), Streptococcus viridians (SV), Moraxella (MS), Haemophilus influenza (HI), Pseudomonas aeruginosa (PA), and Serratia marcescens (SM) are 4, 32, 256, 32, 16, and 128-fold higher, respectively, than SA and SE. Brilacidin has Gram-positive in vitro activity; topical Brilacidin 0.5% is minimally irritating; and Brilacidin 0.5% was equally efficacious as Vancomycin (VAN) in a methicillin-resistant S. aureus (MRSA) keratitis model when the corneal epithelium is removed. Brilacidin acts primarily on the bacterial cell membrane by depolarization. Brilacidin is more potent for Gram-positive bacteria (except SV) than Gram-negative bacteria.

In Vivo: Brilacidin demonstrates dose-dependent ocular toxicity after 7 topical instillations (every 30?min for 3?h) in the NZW rabbit ocular toxicity model. Brilacidin 1% is determined to be Mildly Irritating (23.0), Brilacidin 0.5% (6.5), and Brilacidin 0.25% (4.0) are determined to be Minimally Irritating, while Brilacidin 0.1% (2.0) and TBS (1.0) are determined to be Practically Nonirritating and 0.01% Brilacidin (0.5) is determined to be Nonirritating based on their Maximum mean total scores (MMTS) values.

相关产品：Bioactive Compound Library Plus  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Staurosporine  |  Dexamethasone  |  Etoposide  |  Tunicamycin  |  5-Azacytidine  |  Doxycycline (hyclate)  |  G-418 disulfate  |  CCCP  |  Nigericin sodium salt  |  Resveratrol  |  Tacrolimus  |  Hygromycin B  |  Tanespimycin  |  Streptozocin  |  Vancomycin hydrochloride  |  Ionomycin  |  Anisomycin  |  Neomycin sulfate  |  Ampicillin sodium  |  Avibactam sodium  |  Indomethacin  |  Auranofin  |  Daunorubicin Hydrochloride  |  Gentamicin sulfate  |  Geldanamycin  |  Rifampicin  |  E-64

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。