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LTX-315

CAS No. : 1345407-05-7

MCE 站：LTX-315

产品活性：LTX-315是具有抗癌活性的溶瘤肽，抑制MRC-5，A20 和 AT84的 IC₅₀ 值分别为34.3, 8.3 和 11 µM。

研究领域：Others

作用靶点：Others

In Vitro: LTX-315 is found to be equipotent against drug-resistant cancer cells, nontoxic towards red blood cells, shows high plasma protein binding ａnd is quite rapidly degraded to non-toxic metabolites. LTX-315 induces rapid killing of cancer cells. The oncolytic activity of LTX-315 stems from both a direct lytic effect on the plasma membrane in addition to permeabilization of the mitochondrial membrane, leading to cellular death by necrosis ａnd release of tumor antigens. Treatment of cancer cells with LTX-315 causes the release of several danger signals (DAMPs) that are associated with immunogenic cell death ａnd stimulation of adaptive immune responses.

In Vivo: Intratumoral administration of LTX-315 has resulted in complete regression ａnd systemic tumor specific immune responses in several preclinical models. Intratumoral administration of LTX-315 resulted in tumor necrosis ａnd the infiltration of immune cells into the tumor parenchyma followed by complete regression of the tumor in the majority of the animals. LTX-315 induced the release of danger-associated molecular pattern molecules such as the high mobility group box-1 protein in vitro ａnd the subsequent upregulation of proinflammatory cytokines such as interleukin (IL) 1β, IL6 ａnd IL18 in vivo. Animals cured by LTX-315 treatment are protected against a re-challenge with live B16 tumor cells both intradermally ａnd intravenously.

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