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Nociceptin
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Nociceptin
CAS No. : 170713-75-4
MCE 站:Nociceptin
产品活性:Nociceptin 是一种十七肽,为 nociceptin 受体的内源性配体,具有镇痛作用。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Opioid Receptor
In Vitro: Nociceptin (1 μg/mL) significantly prevents LPS (10 ng/mL)-stimulated cell migration whereas it is ineffective when added alone. Nociceptin (1 nM-10 μM) elicits a concentration-dependent blockade of LPS-mediated cell migration, with a maximal effect at 1 and 10 μM. Nociceptin counteracts LPS-induced elevation of IL-1β mRNA levels. Nociceptin (1 μM) and NNC 55-0396 induce apoptotic cell death in U87 cells. Nociceptin (1 μM) counteracts LPS-induced [Ca2+]i increase in U87 cells via β-arrestin 2. Nociceptin counteracts the LPS-induced phosphorylation of PKC and ERK in U87 cells. Nociceptin inhibits the LPS-mediated transcriptional activation of NF-kB and AP-1 reporter genes.
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